HCSGD entry for MICB
1. General information
| Official gene symbol | MICB |
|---|---|
| Entrez ID | 4277 |
| Gene full name | MHC class I polypeptide-related sequence B |
| Other gene symbols | PERB11.2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001913 | T cell mediated cytotoxicity | IBA | biological_process |
| GO:0002429 | Immune response-activating cell surface receptor signaling pathway | IDA | biological_process |
| GO:0003823 | Antigen binding | IBA | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006955 | Immune response | IEA | biological_process |
| GO:0006979 | Response to oxidative stress | IDA | biological_process |
| GO:0009408 | Response to heat | IDA | biological_process |
| GO:0009986 | Cell surface | ISS | cellular_component |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0019835 | Cytolysis | IEA | biological_process |
| GO:0019882 | Antigen processing and presentation | IBA IEA | biological_process |
| GO:0030881 | Beta-2-microglobulin binding | IBA | molecular_function |
| GO:0032526 | Response to retinoic acid | IDA | biological_process |
| GO:0042267 | Natural killer cell mediated cytotoxicity | IBA | biological_process |
| GO:0046629 | Gamma-delta T cell activation | IDA | biological_process |
| GO:0046703 | Natural killer cell lectin-like receptor binding | IDA | molecular_function |
| GO:0050689 | Negative regulation of defense response to virus by host | IDA | biological_process |
| GO:0050776 | Regulation of immune response | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0221412864 | 0.1581056533 | 0.3564166259 | 0.7682294443 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6558893689 |
| GSE13712_SHEAR | Up | 1.0398369630 |
| GSE13712_STATIC | Up | 0.8779294874 |
| GSE19018 | Down | -0.7383929429 |
| GSE19899_A1 | Down | -0.5005084366 |
| GSE19899_A2 | Up | 0.5033472319 |
| PubMed_21979375_A1 | Up | 0.1957628214 |
| PubMed_21979375_A2 | Down | -0.0015036169 |
| GSE35957 | Down | -0.1837141986 |
| GSE36640 | Up | 0.7795910432 |
| GSE54402 | Down | -0.8610270852 |
| GSE9593 | Up | 0.4275725330 |
| GSE43922 | Up | 0.0355261709 |
| GSE24585 | Up | 1.1167884142 |
| GSE37065 | Up | 0.5304961055 |
| GSE28863_A1 | Down | -0.5048069041 |
| GSE28863_A2 | Up | 0.1440223304 |
| GSE28863_A3 | Down | -0.4392690159 |
| GSE28863_A4 | Down | -0.2668116738 |
| GSE48662 | Down | -0.0463577094 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 19493573 | We show here that pre-treatment of trophoblast cells and certain cancer cells with agents that activate stress pathways (Ras oncogene, PMA or H2O2) and induce senescence can substantially enhance the induction of immune response genes (MHC class II, CD40, MICA, MICB) by HDACi and restore a vigorous IFN-gamma response in trophoblast cells and tumor cells |
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