HCSGD entry for MAP3K11

1. General information

Official gene symbolMAP3K11
Entrez ID4296
Gene full namemitogen-activated protein kinase kinase kinase 11
Other gene symbolsMEKK11 MLK-3 MLK3 PTK1 SPRK
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000080Mitotic G1 phaseIMPbiological_process
GO:0000187Activation of MAPK activityIMPbiological_process
GO:0004672Protein kinase activityTASmolecular_function
GO:0004674Protein serine/threonine kinase activityIDAmolecular_function
GO:0004706JUN kinase kinase kinase activityIEA ISSmolecular_function
GO:0004709MAP kinase kinase kinase activityIEAmolecular_function
GO:0004713Protein tyrosine kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005737CytoplasmIEAcellular_component
GO:0005813CentrosomeIDAcellular_component
GO:0005874MicrotubuleIDAcellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0007017Microtubule-based processIMPbiological_process
GO:0007254JNK cascadeTASbiological_process
GO:0007257Activation of JUN kinase activityIMPbiological_process
GO:0008219Cell deathIEAbiological_process
GO:0008283Cell proliferationIMPbiological_process
GO:0031434Mitogen-activated protein kinase kinase bindingIEAmolecular_function
GO:0031435Mitogen-activated protein kinase kinase kinase bindingIPImolecular_function
GO:0042802Identical protein bindingIPImolecular_function
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0043507Positive regulation of JUN kinase activityIMPbiological_process
GO:0043525Positive regulation of neuron apoptotic processIEAbiological_process
GO:0046330Positive regulation of JNK cascadeIMPbiological_process
GO:0046777Protein autophosphorylationIDA IEAbiological_process
GO:0048365Rac GTPase bindingIEAmolecular_function
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.16819443030.72171446750.80904208701.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0535767594
GSE13712_SHEARUp0.0568165474
GSE13712_STATICDown-0.1038152303
GSE19018Up0.1021441300
GSE19899_A1Up0.1907354607
GSE19899_A2Up0.6257077234
PubMed_21979375_A1Up0.3997487804
PubMed_21979375_A2Up1.4406268836
GSE35957Down-0.2754241431
GSE36640Up0.0192711521
GSE54402Up0.2761713411
GSE9593Down-0.0954326051
GSE43922Up0.2693549357
GSE24585Up0.0341055061
GSE37065Up0.1430455647
GSE28863_A1Down-0.1246750066
GSE28863_A2Down-0.2027516772
GSE28863_A3Down-0.4200983002
GSE28863_A4Up0.0170454739
GSE48662Down-0.3151557367

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-199a-5pMIMAT0000231MIRT005873Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI21048306
Entries Per Page
Displaying Page of
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.