HCSGD entry for MME

1. General information

Official gene symbolMME
Entrez ID4311
Gene full namemembrane metallo-endopeptidase
Other gene symbolsCALLA CD10 NEP SFE
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001822Kidney developmentIEPbiological_process
GO:0002003Angiotensin maturationTASbiological_process
GO:0004175Endopeptidase activityIDA IMPmolecular_function
GO:0004222Metalloendopeptidase activityIEA IMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005887Integral component of plasma membraneNAScellular_component
GO:0005903Brush borderIDAcellular_component
GO:0006508ProteolysisIDA IEAbiological_process
GO:0006518Peptide metabolic processISSbiological_process
GO:0008021Synaptic vesicleIEA ISScellular_component
GO:0008270Zinc ion bindingIDAmolecular_function
GO:0016020MembraneIEAcellular_component
GO:0016021Integral component of membraneNAScellular_component
GO:0019233Sensory perception of painIEA ISSbiological_process
GO:0030424AxonIEA ISScellular_component
GO:0030425DendriteIEA ISScellular_component
GO:0042277Peptide bindingIEA ISSmolecular_function
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0044306Neuron projection terminusIEA ISScellular_component
GO:0045202SynapseISScellular_component
GO:0046449Creatinine metabolic processIMPbiological_process
GO:0050435Beta-amyloid metabolic processIEA ISSbiological_process
GO:0071345Cellular response to cytokine stimulusIDAbiological_process
GO:0071492Cellular response to UV-AIDAbiological_process
GO:0071493Cellular response to UV-BIDAbiological_process
GO:0090399Replicative senescenceIEPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00008459410.12865190150.02714096390.6903842813

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0182609441
GSE13712_SHEARUp0.0669970572
GSE13712_STATICUp0.1708724601
GSE19018Down-0.5688749844
GSE19899_A1Up4.9628297598
GSE19899_A2Up3.2970377030
PubMed_21979375_A1Up5.0084211059
PubMed_21979375_A2Up6.2156443187
GSE35957Up0.4456686670
GSE36640Down-2.3896731874
GSE54402Up0.9687407360
GSE9593Up0.5915921503
GSE43922Up3.3185070939
GSE24585Up0.6830168204
GSE37065Up0.9271724912
GSE28863_A1Down-0.0162028833
GSE28863_A2Down-0.1370263598
GSE28863_A3Up0.3689792377
GSE28863_A4Down-0.8091061867
GSE48662Up0.4852277358

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

OmapatrilatDB00886 APRD00443
N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1'-Biphenyl-4-Ylmethyl)Propanoyl]AlanineDB02062 EXPT00710
PhosphoramidonDB02557 EXPT02764
N-(3-Phenyl-2-Sulfanylpropanoyl)PhenylalanylalanineDB02558 EXPT02428
[2(R,S)-2-Sulfanylheptanoyl]-Phe-AlaDB02597 EXPT03060
SLV 306DB05796 -
2-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUMDB08575 -
ThiorphanDB08626 DB01654
SacubitrilDB09292 -
CandoxatrilatDB11623 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT023833MicroarrayFunctional MTI (Weak)18668037
hsa-miR-26b-5pMIMAT0000083MIRT029646MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

20225285The expressions of CD166, CD49a, and CD106 decreased, whereas those of CD10, CD29, CD44, CD73, CD90, and CD105 showed no significant change
9032753Enzyme neutral endopeptidase (EC 3
7020767The calculated half-lives were: 60 days for the neutral endopeptidase; 87 days for the total acidic endopeptidase activity which is accounted for by three distinct enzymes; 49 days for aminopeptidase B and 133 days for a second aminopeptidase with broad substrate specificity; 84 days for dipeptidyl aminopeptidase II
7020767The results obtained with the rabbit erythrocytes were: (a) no significant decline of leucine aminopeptidase, dipeptidyl aminopeptidase II and III activities in the transition from reticulocytes to mature erythrocytes; (b) very limited decline of aminopeptidase B activity; (c) a pronounced age-dependent decay, in increasing order, of neutral endopeptidase, aminopeptidase A, carboxypeptidase and acidic endopeptidase activities
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