HCSGD entry for MRC1
1. General information
| Official gene symbol | MRC1 |
|---|---|
| Entrez ID | 4360 |
| Gene full name | mannose receptor, C type 1 |
| Other gene symbols | CD206 CLEC13D CLEC13DL MMR MRC1L1 bA541I19.1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004872 | Receptor activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005537 | Mannose binding | TAS | molecular_function |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006898 | Receptor-mediated endocytosis | IDA | biological_process |
| GO:0010008 | Endosome membrane | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7457083659 | 0.2129867254 | 0.9999902473 | 0.8911180416 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0109772173 |
| GSE13712_SHEAR | Down | -0.2680251174 |
| GSE13712_STATIC | Down | -0.1080821670 |
| GSE19018 | Down | -0.0427665706 |
| GSE19899_A1 | Up | 0.3192698177 |
| GSE19899_A2 | Down | -0.0121603635 |
| PubMed_21979375_A1 | Up | 0.0637462545 |
| PubMed_21979375_A2 | Up | 0.2009125627 |
| GSE35957 | Down | -0.4981393638 |
| GSE36640 | Up | 0.2623713558 |
| GSE54402 | Down | -0.0329728058 |
| GSE9593 | Down | -0.8262456878 |
| GSE43922 | Up | 0.0132665551 |
| GSE24585 | Down | -0.1282831632 |
| GSE37065 | Down | -0.0320077288 |
| GSE28863_A1 | Down | -0.1072571637 |
| GSE28863_A2 | Down | -0.1591885262 |
| GSE28863_A3 | Up | 0.2691288945 |
| GSE28863_A4 | Down | -0.2453093839 |
| GSE48662 | Up | 0.0825526562 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 18567801 | To determine the potential mechanisms of senescence-dependent increases in genomic instability, we analyzed DNA mismatch repair (MMR) efficiency in young and senescent human colonic fibroblast and human embryonic lung fibroblast |
| 18567801 | It was found that MMR activity is significantly reduced in senescent cells |
| 18567801 | Western blot and immunohistochemistry analysis revealed that hMSH2 and MSH6 protein (MutS alpha complex), which is a known key component in the MMR pathway, is markedly down-regulated in senescent cells |
| 18567801 | Moreover, the addition of purified MutS alpha to extracts from senescent cells led to the restoration of MMR activity |
| 18567801 | E2F1 small interfering RNA expression reduced hMSH2 expression and MMR activity in young human primary fibroblast cells |
| 18567801 | Importantly, expression of E2F1 in quiescent cells restored the MSH2 expression as well as MMR activity, whereas E2F1-infected senescent cells exhibited no restoration of MSH2 expression and MMR activity |
| 18567801 | These results indicate that the suppression of E2F1 transcriptional activity in senescent cells lead to stable repression of MSH2, followed by a induction of MutS alpha dysfunction, which results in a reduced cellular MMR capacity in senescent cells |
| 18089797 | Furthermore, v5 was preferentially expressed in mismatch repair (MMR)-deficient cells and tumor tissues, suggesting its role in chromosome stability associated with MMR deficiency |
| 16216462 | This study employed an in vitro model of human CD4+T cell ageing to investigate MMR capacity at various stages of T cell lifespan |
| 16216462 | However, when challenged with supra-physiological levels of DNA mismatches, deficiencies were found in ageing T cell clones in MMR capacity, with the exception of T cell clones from a SENIEUR donor previously shown to maintain effective DNA excision repair |
| 15760303 | Activation of Mrc1, a mediator of the replication checkpoint, by telomere erosion |
| 15760303 | In telomerase-negative cells deleted for RAD9, Mrc1, another checkpoint adaptor previously implicated in the DNA replication checkpoint, mediated Rad53 activation |
| 15760303 | However, unexpectedly, given the formation of an active Rad53-Mrc1 complex in tlc1Delta rad9Delta cells, Mrc1 did not mediate the cell-cycle arrest elicited by telomerase loss |
| 15760303 | Finally, we report that Rad9, Mrc1, Dun1 and Chk1 are activated by phosphorylation after telomerase inactivation |
| 15050284 | We showed significantly higher rates of microsatellite instability (MSI), an indicator of MMR dysfunction in older subjects, compared to young |
| 11479224 | Temozolomide (TMZ) produces O(6)-methylguanine in DNA, which in turn mispairs with thymine, triggering futile DNA mismatch repair (MMR) and ultimately cell death |
| 11479224 | We found previously that in p53-proficient human glioma cells, TMZ-induced futile DNA MMR resulted not in apoptosis but rather in prolonged, p53- and p21-associated G(2)-M arrest and senescence |
| 11479224 | Taken together, these results indicate that Chk1 links TMZ-induced MMR to G(2)-M arrest |
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