HCSGD entry for MUC4
1. General information
| Official gene symbol | MUC4 |
|---|---|
| Entrez ID | 4585 |
| Gene full name | mucin 4, cell surface associated |
| Other gene symbols | ASGP HSA276359 MUC-4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005176 | ErbB-2 class receptor binding | TAS | molecular_function |
| GO:0005578 | Proteinaceous extracellular matrix | NAS | cellular_component |
| GO:0005796 | Golgi lumen | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0007160 | Cell-matrix adhesion | IEA | biological_process |
| GO:0008150 | Biological_process | ND | biological_process |
| GO:0016020 | Membrane | NAS | cellular_component |
| GO:0016266 | O-glycan processing | TAS | biological_process |
| GO:0030197 | Extracellular matrix constituent, lubricant activity | NAS | molecular_function |
| GO:0043687 | Post-translational protein modification | TAS | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5969042362 | 0.9173825121 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0173938320 |
| GSE13712_SHEAR | Up | 0.0212463663 |
| GSE13712_STATIC | Up | 0.0571914975 |
| GSE19018 | Up | 0.1080144545 |
| GSE19899_A1 | Up | 0.0323609977 |
| GSE19899_A2 | Up | 0.0940133611 |
| PubMed_21979375_A1 | Down | -0.0784328653 |
| PubMed_21979375_A2 | Up | 0.0228834247 |
| GSE35957 | Up | 0.1154544016 |
| GSE36640 | Up | 0.0523777904 |
| GSE54402 | Up | 0.0325894704 |
| GSE9593 | Down | -0.0678937815 |
| GSE43922 | Up | 0.0225395061 |
| GSE24585 | Up | 0.1726407054 |
| GSE37065 | Down | -0.1344277296 |
| GSE28863_A1 | Down | -0.1622561852 |
| GSE28863_A2 | Up | 0.0064163485 |
| GSE28863_A3 | Up | 0.3561796502 |
| GSE28863_A4 | Up | 0.1384925204 |
| GSE48662 | Up | 0.1621335468 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017552 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-150-5p | MIMAT0000451 | 1 | hsa-miR-150 | {Western blot} | {overexpression by miRNA mimics tranfection} | 21983127 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24747969 | MUC4, a high molecular weight glycoprotein, is differentially overexpressed in many human cancers and implicated in cancer progression and resistance to several chemotherapies |
| 24747969 | This study revealed a significant upregulation of MUC4 in 78% (68/87) of HNSCC tissues compared with 10% positivity (1/10) in benign samples (P=0 |
| 24747969 | Orthotopic implantation of MUC4 KD SCC1 cells into the floor of the mouth in nude mice resulted in the formation of significantly smaller tumors (170+/-18 |
| 24747969 | In conclusion, our findings showed that MUC4 overexpression has a critical role by regulating proliferation and cellular senescence of HNSCC cells |
| 24747969 | Downregulation of MUC4 may be a promising therapeutic approach for treating HNSCC patients |
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