HCSGD entry for NDUFS1

1. General information

Official gene symbolNDUFS1
Entrez ID4719
Gene full nameNADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
Other gene symbolsCI-75Kd CI-75k PRO1304
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005515Protein bindingIPImolecular_function
GO:0005739MitochondrionIEAcellular_component
GO:0005743Mitochondrial inner membraneTAScellular_component
GO:0005747Mitochondrial respiratory chain complex IIDA IMP NAScellular_component
GO:0005758Mitochondrial intermembrane spaceIDAcellular_component
GO:0006120Mitochondrial electron transport, NADH to ubiquinoneNASbiological_process
GO:0008137NADH dehydrogenase (ubiquinone) activityIEA IMP NASmolecular_function
GO:0008637Apoptotic mitochondrial changesIDAbiological_process
GO:0009055Electron carrier activityIEA NASmolecular_function
GO:0016020MembraneIEAcellular_component
GO:0022904Respiratory electron transport chainTASbiological_process
GO:0042773ATP synthesis coupled electron transportIEAbiological_process
GO:0044237Cellular metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045333Cellular respirationIMPbiological_process
GO:0046034ATP metabolic processIMPbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0051536Iron-sulfur cluster bindingIEAmolecular_function
GO:00515372 iron, 2 sulfur cluster bindingIEAmolecular_function
GO:00515394 iron, 4 sulfur cluster bindingIEAmolecular_function
GO:0051881Regulation of mitochondrial membrane potentialIMPbiological_process
GO:0072593Reactive oxygen species metabolic processIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.29162477870.60522387450.99094446171.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1301668967
GSE13712_SHEARUp0.1169280022
GSE13712_STATICUp0.0429701810
GSE19018Down-0.0725657536
GSE19899_A1Up0.1269300463
GSE19899_A2Down-0.0142308062
PubMed_21979375_A1Down-0.1489569768
PubMed_21979375_A2Down-0.0317828568
GSE35957Down-0.1889313357
GSE36640Up0.2581682828
GSE54402Down-0.0672783406
GSE9593Down-0.0372638607
GSE43922Down-0.0325617805
GSE24585Up0.3244927186
GSE37065Down-0.0628649183
GSE28863_A1Up0.6156060158
GSE28863_A2Up0.7682258810
GSE28863_A3Down-0.3205643957
GSE28863_A4Down-0.2741934987
GSE48662Down-0.1277405016

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NADHDB00157 NUTR00041 | DB01907 | EXPT02287 | DB03527

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-615-3pMIMAT0003283MIRT040441CLASHFunctional MTI (Weak)23622248
hsa-miR-324-5pMIMAT0000761MIRT043105CLASHFunctional MTI (Weak)23622248
hsa-miR-221-3pMIMAT0000278MIRT046974CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.