HCSGD entry for ATP1A2
1. General information
| Official gene symbol | ATP1A2 |
|---|---|
| Entrez ID | 477 |
| Gene full name | ATPase, Na+/K+ transporting, alpha 2 polypeptide |
| Other gene symbols | FHM2 MHP2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001504 | Neurotransmitter uptake | IEA | biological_process |
| GO:0002026 | Regulation of the force of heart contraction | IEA | biological_process |
| GO:0002087 | Regulation of respiratory gaseous exchange by neurological system process | IEA | biological_process |
| GO:0005391 | Sodium:potassium-exchanging ATPase activity | IMP | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005768 | Endosome | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IDA TAS | cellular_component |
| GO:0005890 | Sodium:potassium-exchanging ATPase complex | IC | cellular_component |
| GO:0005901 | Caveola | IEA | cellular_component |
| GO:0006200 | ATP catabolic process | IMP | biological_process |
| GO:0006754 | ATP biosynthetic process | IEA | biological_process |
| GO:0006813 | Potassium ion transport | NAS | biological_process |
| GO:0006814 | Sodium ion transport | NAS | biological_process |
| GO:0006940 | Regulation of smooth muscle contraction | IEA | biological_process |
| GO:0006942 | Regulation of striated muscle contraction | NAS | biological_process |
| GO:0008217 | Regulation of blood pressure | IEA | biological_process |
| GO:0008344 | Adult locomotory behavior | IEA | biological_process |
| GO:0008542 | Visual learning | IEA | biological_process |
| GO:0015077 | Monovalent inorganic cation transmembrane transporter activity | IEA | molecular_function |
| GO:0015991 | ATP hydrolysis coupled proton transport | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0019229 | Regulation of vasoconstriction | IEA | biological_process |
| GO:0019829 | Cation-transporting ATPase activity | IEA | molecular_function |
| GO:0030315 | T-tubule | IEA | cellular_component |
| GO:0034220 | Ion transmembrane transport | TAS | biological_process |
| GO:0035094 | Response to nicotine | IEA | biological_process |
| GO:0035725 | Sodium ion transmembrane transport | IMP | biological_process |
| GO:0040011 | Locomotion | IEA | biological_process |
| GO:0043197 | Dendritic spine | IEA | cellular_component |
| GO:0045202 | Synapse | IEA | cellular_component |
| GO:0045822 | Negative regulation of heart contraction | IEA | biological_process |
| GO:0045988 | Negative regulation of striated muscle contraction | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0051481 | Negative regulation of cytosolic calcium ion concentration | IEA | biological_process |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
| GO:0071260 | Cellular response to mechanical stimulus | IEA | biological_process |
| GO:0071805 | Potassium ion transmembrane transport | IMP | biological_process |
| GO:0086004 | Regulation of cardiac muscle cell contraction | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5417912845 | 0.9067531743 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0236408375 |
| GSE13712_SHEAR | Up | 0.0043408775 |
| GSE13712_STATIC | Up | 0.0032825650 |
| GSE19018 | Up | 0.0891662595 |
| GSE19899_A1 | Up | 0.1032282000 |
| GSE19899_A2 | Up | 0.0153405519 |
| PubMed_21979375_A1 | Up | 0.0707476028 |
| PubMed_21979375_A2 | Down | -0.0560935155 |
| GSE35957 | Up | 0.1815568844 |
| GSE36640 | Down | -0.1884084424 |
| GSE54402 | Down | -0.0809631014 |
| GSE9593 | Down | -0.0431199848 |
| GSE43922 | Up | 0.0544503854 |
| GSE24585 | Up | 0.1128128808 |
| GSE37065 | Up | 0.0354510713 |
| GSE28863_A1 | Up | 0.0506598314 |
| GSE28863_A2 | Up | 0.2189942630 |
| GSE28863_A3 | Up | 0.1876314609 |
| GSE28863_A4 | Down | -0.0181107746 |
| GSE48662 | Up | 0.2027770120 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-122-5p | MIMAT0000421 | MIRT003095 | Luciferase reporter assay//qRT-PCR | Functional MTI | 19296470 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047687 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048595 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26171229 | EDH-type relaxations in WKY were reduced with aging, and this was associated with an impairment of the function of small-conductance calcium-activated potassium channels (SKC a) and sodium-potassium ATPase (Na-K ATPase) |
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