HCSGD entry for NPPC

1. General information

Official gene symbolNPPC
Entrez ID4880
Gene full namenatriuretic peptide C
Other gene symbolsCNP CNP2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001503OssificationIEAbiological_process
GO:0001666Response to hypoxiaIEAbiological_process
GO:0003418Growth plate cartilage chondrocyte differentiationISSbiological_process
GO:0003419Growth plate cartilage chondrocyte proliferationISSbiological_process
GO:0005102Receptor bindingIPImolecular_function
GO:0005179Hormone activityIEAmolecular_function
GO:0005615Extracellular spaceIEAcellular_component
GO:0006182CGMP biosynthetic processIDAbiological_process
GO:0007168Receptor guanylyl cyclase signaling pathwayIDAbiological_process
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0009791Post-embryonic developmentIEAbiological_process
GO:0030141Secretory granuleIEAcellular_component
GO:0030828Positive regulation of cGMP biosynthetic processIEAbiological_process
GO:0040014Regulation of multicellular organism growthIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0045471Response to ethanolIEAbiological_process
GO:0045669Positive regulation of osteoblast differentiationIEAbiological_process
GO:0045909Positive regulation of vasodilationIEAbiological_process
GO:0048660Regulation of smooth muscle cell proliferationIEAbiological_process
GO:0050880Regulation of blood vessel sizeIEAbiological_process
GO:0051053Negative regulation of DNA metabolic processIEAbiological_process
GO:0051428Peptide hormone receptor bindingIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.17847587480.77486665780.82851208111.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0395947571
GSE13712_SHEARDown-0.8583421270
GSE13712_STATICDown-0.1405538442
GSE19018Up0.0091338668
GSE19899_A1Up0.1728925598
GSE19899_A2Up0.0640719347
PubMed_21979375_A1Up0.0860947026
PubMed_21979375_A2Down-0.2612504578
GSE35957Up0.0918759114
GSE36640Up0.0334697139
GSE54402Up0.1741859246
GSE9593Up0.0510041886
GSE43922Up0.4607844496
GSE24585Up0.0773286416
GSE37065Up0.0200503714
GSE28863_A1Up0.2278394065
GSE28863_A2Up0.1314010830
GSE28863_A3Up0.5692767239
GSE28863_A4Up0.1297472316
GSE48662Down-0.0833945889

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-193b-3pMIMAT0002819MIRT016398MicroarrayFunctional MTI (Weak)20304954
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.