HCSGD entry for ROR2

1. General information

Official gene symbolROR2
Entrez ID4920
Gene full namereceptor tyrosine kinase-like orphan receptor 2
Other gene symbolsBDB BDB1 NTRKR2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001502Cartilage condensationIEAbiological_process
GO:0001756SomitogenesisIEAbiological_process
GO:0004713Protein tyrosine kinase activityIEAmolecular_function
GO:0004714Transmembrane receptor protein tyrosine kinase activityIEAmolecular_function
GO:0005109Frizzled bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0007165Signal transductionTASbiological_process
GO:0007169Transmembrane receptor protein tyrosine kinase signaling pathwayIEAbiological_process
GO:0007223Wnt signaling pathway, calcium modulating pathwayIEAbiological_process
GO:0007254JNK cascadeIEAbiological_process
GO:0007275Multicellular organismal developmentTASbiological_process
GO:0008285Negative regulation of cell proliferationIMPbiological_process
GO:0017147Wnt-protein bindingIPImolecular_function
GO:0018108Peptidyl-tyrosine phosphorylationTASbiological_process
GO:0030154Cell differentiationIEAbiological_process
GO:0030335Positive regulation of cell migrationIDAbiological_process
GO:0030538Embryonic genitalia morphogenesisIEAbiological_process
GO:0042472Inner ear morphogenesisIEAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIEAbiological_process
GO:0060071Wnt signaling pathway, planar cell polarity pathwayIEAbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayIEAbiological_process
GO:0090263Positive regulation of canonical Wnt signaling pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.93301977510.02982205080.99999024730.3263840748

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2771585806
GSE13712_SHEARUp0.0276218072
GSE13712_STATICDown-0.0386695281
GSE19018Down-0.5289894322
GSE19899_A1Down-0.0324808377
GSE19899_A2Down-0.7519451437
PubMed_21979375_A1Down-0.5788074865
PubMed_21979375_A2Down-0.3937309843
GSE35957Up0.0601158901
GSE36640Down-1.2696166746
GSE54402Down-1.1520948733
GSE9593Down-0.0315666763
GSE43922Down-0.0790287194
GSE24585Down-0.0766914146
GSE37065Down-0.1251127891
GSE28863_A1Up0.3275826112
GSE28863_A2Up0.5611448780
GSE28863_A3Up0.0752199680
GSE28863_A4Up0.0863391441
GSE48662Up0.0600205489

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT016864MicroarrayFunctional MTI (Weak)18185580
hsa-let-7f-5pMIMAT0000067MIRT051386CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.