HCSGD entry for NTS
1. General information
| Official gene symbol | NTS |
|---|---|
| Entrez ID | 4922 |
| Gene full name | neurotensin |
| Other gene symbols | NMN-125 NN NT NT/N NTS1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005184 | Neuropeptide hormone activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | IEA TAS | cellular_component |
| GO:0007165 | Signal transduction | NAS | biological_process |
| GO:0030133 | Transport vesicle | IEA | cellular_component |
| GO:0050880 | Regulation of blood vessel size | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2106860720 | 0.1443275901 | 0.8844925040 | 0.7317346554 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3868075585 |
| GSE13712_SHEAR | Down | -1.4555831634 |
| GSE13712_STATIC | Up | 0.1488227977 |
| GSE19018 | Down | -0.1196960875 |
| GSE19899_A1 | Up | 0.1085814083 |
| GSE19899_A2 | Up | 0.4815621690 |
| PubMed_21979375_A1 | Up | 0.1596225450 |
| PubMed_21979375_A2 | Up | 0.2242731857 |
| GSE35957 | Up | 0.3872830935 |
| GSE36640 | Up | 0.0246585440 |
| GSE54402 | Up | 1.5627638711 |
| GSE9593 | Down | -0.2178304699 |
| GSE43922 | Up | 0.0216926083 |
| GSE24585 | Down | -0.3419015856 |
| GSE37065 | Down | -0.0065417894 |
| GSE28863_A1 | Up | 0.1642364494 |
| GSE28863_A2 | Down | -0.0302129609 |
| GSE28863_A3 | Down | -0.9720355950 |
| GSE28863_A4 | Down | -0.4789106069 |
| GSE48662 | Down | -0.0437981403 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25248920 | By contrast, we found that Jhd2, an evolutionarily conserved JARID1 family H3 Lys4 demethylase, effects all states of methylated H3K4 within the NTS regions of rDNA and that its activity is required for the regulation of rDNA silencing in a Sir2-independent manner |
| 25248920 | In this context, Jhd2 regulates rDNA recombination through the Tof2/Csm1/Lrs4 pathway and prevents excessive recruitment of Tof2, Csm1/Lrs4 and condensin subunits to the replication fork barrier (RFB) site within the NTS1 region |
| 25248920 | These data suggest that Jhd2-mediated alleviation of excessive Csm1/Lrs4 or condensin at the NTS1 region of rDNA is required for the integrity of rDNA repeats and proper rDNA silencing during mitosis |
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