HCSGD entry for OGG1

1. General information

Official gene symbolOGG1
Entrez ID4968
Gene full name8-oxoguanine DNA glycosylase
Other gene symbolsHMMH HOGG1 MUTM OGH1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002526Acute inflammatory responseIEAbiological_process
GO:0003684Damaged DNA bindingIEAmolecular_function
GO:0003824Catalytic activityIEAmolecular_function
GO:0004519Endonuclease activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmIDA TAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0006281DNA repairIEA TASbiological_process
GO:0006284Base-excision repairIEA TASbiological_process
GO:0006285Base-excision repair, AP site formationTASbiological_process
GO:0006289Nucleotide-excision repairIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIMPbiological_process
GO:0006979Response to oxidative stressIDAbiological_process
GO:0008017Microtubule bindingIEAmolecular_function
GO:0008534Oxidized purine nucleobase lesion DNA N-glycosylase activityIEA TASmolecular_function
GO:0009314Response to radiationIDAbiological_process
GO:0016363Nuclear matrixIDAcellular_component
GO:0016607Nuclear speckIDAcellular_component
GO:0032355Response to estradiolIEAbiological_process
GO:0033158Regulation of protein import into nucleus, translocationIDAbiological_process
GO:00340398-oxo-7,8-dihydroguanine DNA N-glycosylase activityIEAmolecular_function
GO:0042493Response to drugIEAbiological_process
GO:0045007DepurinationTASbiological_process
GO:0045471Response to ethanolIEAbiological_process
GO:0051593Response to folic acidIEAbiological_process
GO:0071276Cellular response to cadmium ionIEAbiological_process
GO:0090305Nucleic acid phosphodiester bond hydrolysisTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.93306614490.24369629190.99999024730.9505527712

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0666975942
GSE13712_SHEARUp0.0265560850
GSE13712_STATICUp0.0131968425
GSE19018Up0.0497358770
GSE19899_A1Down-0.1130109489
GSE19899_A2Down-0.2652639791
PubMed_21979375_A1Down-0.3009210060
PubMed_21979375_A2Down-0.4465980037
GSE35957Down-0.1720007213
GSE36640Down-0.3589578512
GSE54402Down-0.0854518274
GSE9593Down-0.1967124123
GSE43922Up0.0531458494
GSE24585Up0.1074649675
GSE37065Down-0.1090686045
GSE28863_A1Down-0.0050947737
GSE28863_A2Down-0.0986626910
GSE28863_A3Up0.1729163972
GSE28863_A4Up0.1009156856
GSE48662Up0.0664069785

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-615-3pMIMAT0003283MIRT040345CLASHFunctional MTI (Weak)23622248
hsa-miR-1260bMIMAT0015041MIRT052750CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 9 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25921542Accordingly, LPC provoked oxidative DNA injury, whereas the gene expressions of DNA repair enzyme (OGG1, MUTYH, MTH1) remained unchanged
25682875Structure/function analysis established that a single Cut repeat domain can stimulate the DNA binding, Schiff-base formation, glycosylase and AP-lyase activities of 8-oxoguanine DNA glycosylase 1, OGG1
25682875Strikingly and in contrast to previous reports, OGG1 exhibits efficient AP-lyase activity in the presence of a Cut repeat
25682875Repair of oxidative DNA damage and proliferation in 20% oxygen were both rescued in Cux1-/- MEFs by ectopic expression of CUX1 or of a recombinant Cut repeat protein that stimulates OGG1 but is devoid of transcription activation potential
24618719Here we show that CUX1 functions in base excision repair as an ancillary factor for the 8-oxoG-DNA glycosylase, OGG1
24618719We show that elevated expression of either CUX1 or OGG1 prevents RAS-induced senescence in primary cells, and that CUX1 knockdown is synthetic lethal with oncogenic RAS in human cancer cells
24589083PROBLEM: The most common DNA lesion generated by oxidative stress (OS) is 7, 8-dihydro-8-oxoguanine (8-oxoG) whose excision repair is performed by 8-oxoguanine glycosylase (OGG1)
24589083OGG1 mRNA expression and localization in fetal membranes from clinical specimens and in normal term membranes exposed to CSE were examined by QRT-PCR and by immunohistochemistry
24589083OGG1 expression was 2
24589083CSE treatment showed a nonsignificant decrease in OGG1
24589083OGG1 was localized to both amnion and chorion with less intense staining in pPROM and CSE-treated membranes
24589083CONCLUSION: Increased OS-induced DNA damage predominated by 8-oxoG is likely to persist in fetal cells due to reduced availability of base excision repair enzyme OGG1
23744553Eight-hydroxydeoxyguanosine, the main oxidative DNA adduct, is partially repaired by a glycosylase (OGG1) whose polymorphism is associated to a reduced repair capacity
23744553This study aimed to evaluate the link among 8-hydroxydeoxyguanosine, OGG1 polymorphism, telomerase activity, telomere length, and p53 mutation in Barrett progression
23744553Analysis of biopsy samples was undertaken to study 8-hydroxydeoxyguanosine levels, OGG1 polymorphism, telomerase activity, and telomere length
23185405We have also quantified the transcripts of genes involved in the repair of oxidative DNA damage at telomeres (OGG1), telomere regulation and elongation (TERT), and in the response to biopsychological stress (FOS and DUSP1)
23185405RESULTS: The OGG1, p16(INK4a), and STMN1 gene were significantly up-regulated (25 to 100%) in the leucocytes of MDD patients
20951653Factors that influence telomeric oxidative base damage and repair by DNA glycosylase OGG1
209516537,8-Dihydro-8-oxogaunine (8-oxodG) is one of the most abundant oxidative guanine lesions, and 8-oxoguanine DNA glycosylase (OGG1) is involved in its removal
20951653In this study, we examined if telomeric DNA is particularly susceptible to oxidative base damage and if telomere-specific factors affect the incision of oxidized guanines by OGG1
20951653We also showed that the 8-oxodG-incision activity of OGG1 is similar in telomeric and non-telomeric double-stranded substrates
16122734Both replicating and senescing NHOK expressed readily detectable 8-oxo-dG DNA glycosylase (hOGG1), the enzyme responsible for glycosidic cleavage of 8-oxo-dG
16122734These results indicated that senescing NHOK accumulated oxidative DNA lesions in part due to increased level of endogenous ROS and impaired intranuclear translocation of hOGG1 enzyme upon exposure to oxidative stress
12841596Age-associated decrease of oxidative repair enzymes, human 8-oxoguanine DNA glycosylases (hOgg1), in human aging
12841596The 8-oxoguanine repair-specific enzyme 8-oxoguanine-DNA glycosylase (hOgg1) was recently cloned and was observed to conduct mainly short-patch base-excision repair
12841596We explored the association between the hOgg1 enzyme activity in somatic cells of human subjects of various ages and the role of hOgg1(326) genetic polymorphism
12841596The hOgg1 repair activity toward the radiolabelled 8-oxoguanine-containing DNA was determined, and the results indicated a significant age-dependent decrease in the hOgg1 activity in their lymphocytes
12841596These results provide an important observation regarding the cellular hOgg1 activity in somatic cells during the normal human aging processes
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