HCSGD entry for P2RX3

1. General information

Official gene symbolP2RX3
Entrez ID5024
Gene full namepurinergic receptor P2X, ligand-gated ion channel, 3
Other gene symbolsP2X3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001614Purinergic nucleotide receptor activityIBA IEA NASmolecular_function
GO:0001666Response to hypoxiaIEAbiological_process
GO:0004931Extracellular ATP-gated cation channel activityIBA IEA NASmolecular_function
GO:0005524ATP bindingIEA NASmolecular_function
GO:0005791Rough endoplasmic reticulumIEAcellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006810TransportTASbiological_process
GO:0006812Cation transportIBAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007274Neuromuscular synaptic transmissionIEAbiological_process
GO:0009408Response to heatIEAbiological_process
GO:0009409Response to coldIEAbiological_process
GO:0009612Response to mechanical stimulusIEAbiological_process
GO:0009743Response to carbohydrateIEAbiological_process
GO:0010524Positive regulation of calcium ion transport into cytosolNASbiological_process
GO:0014832Urinary bladder smooth muscle contractionIEAbiological_process
GO:0016020MembraneIBAcellular_component
GO:0019228Neuronal action potentialIEAbiological_process
GO:0030432PeristalsisIEAbiological_process
GO:0033198Response to ATPIEAbiological_process
GO:0034220Ion transmembrane transportIBA NAS TASbiological_process
GO:0035587Purinergic receptor signaling pathwayIBA NASbiological_process
GO:0035590Purinergic nucleotide receptor signaling pathwayIBA NASbiological_process
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043195Terminal boutonIEAcellular_component
GO:0043197Dendritic spineIEAcellular_component
GO:0043235Receptor complexIDAcellular_component
GO:0045121Membrane raftIEAcellular_component
GO:0048167Regulation of synaptic plasticityIEAbiological_process
GO:0048266Behavioral response to painIEAbiological_process
GO:0050850Positive regulation of calcium-mediated signalingNASbiological_process
GO:0050909Sensory perception of tasteIEAbiological_process
GO:0051260Protein homooligomerizationIEAbiological_process
GO:0055085Transmembrane transportIBA NAS TASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.29962202420.93555138860.99882756311.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0038639493
GSE13712_SHEARUp0.0868328566
GSE13712_STATICUp0.0819826101
GSE19018Up0.1293201715
GSE19899_A1Up0.3033085781
GSE19899_A2Down-0.0597683018
PubMed_21979375_A1Up0.2157792995
PubMed_21979375_A2Up0.0989437116
GSE35957Down-0.1283994191
GSE36640Up0.0651410067
GSE54402Up0.0333998234
GSE9593Down-0.0466106178
GSE43922Up0.0277648356
GSE24585Up0.1722349913
GSE37065Down-0.0922888867
GSE28863_A1Down-0.0374731606
GSE28863_A2Up0.1698149523
GSE28863_A3Up0.3116723510
GSE28863_A4Up0.0528252302
GSE48662Up0.1547757469

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.