HCSGD entry for P4HB
1. General information
| Official gene symbol | P4HB |
|---|---|
| Entrez ID | 5034 |
| Gene full name | prolyl 4-hydroxylase, beta polypeptide |
| Other gene symbols | DSI ERBA2L GIT P4Hbeta PDI PDIA1 PHDB PO4DB PO4HB PROHB |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003756 | Protein disulfide isomerase activity | IEA | molecular_function |
| GO:0004656 | Procollagen-proline 4-dioxygenase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | NAS | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005788 | Endoplasmic reticulum lumen | TAS | cellular_component |
| GO:0005793 | Endoplasmic reticulum-Golgi intermediate compartment | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0006662 | Glycerol ether metabolic process | IEA | biological_process |
| GO:0015035 | Protein disulfide oxidoreductase activity | IEA | molecular_function |
| GO:0016222 | Procollagen-proline 4-dioxygenase complex | IDA | cellular_component |
| GO:0016853 | Isomerase activity | IEA | molecular_function |
| GO:0018401 | Peptidyl-proline hydroxylation to 4-hydroxy-L-proline | IDA | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0034976 | Response to endoplasmic reticulum stress | IMP | biological_process |
| GO:0042157 | Lipoprotein metabolic process | TAS | biological_process |
| GO:0042470 | Melanosome | IEA | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045454 | Cell redox homeostasis | IEA | biological_process |
| GO:0046982 | Protein heterodimerization activity | IEA | molecular_function |
| GO:0055114 | Oxidation-reduction process | IDA TAS | biological_process |
| GO:0071456 | Cellular response to hypoxia | IMP | biological_process |
| GO:1902175 | Regulation of intrinsic apoptotic signaling pathway in response to oxidative stress | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1860474374 | 0.3976158011 | 0.8418291946 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0518083100 |
| GSE13712_SHEAR | Up | 0.4837846127 |
| GSE13712_STATIC | Up | 0.3821345927 |
| GSE19018 | Up | 0.6357509991 |
| GSE19899_A1 | Down | -0.4280942101 |
| GSE19899_A2 | Up | 0.0472351357 |
| PubMed_21979375_A1 | Up | 0.2093651325 |
| PubMed_21979375_A2 | Down | -1.2688294648 |
| GSE35957 | Down | -0.3911296350 |
| GSE36640 | Up | 0.1219895122 |
| GSE54402 | Down | -0.1337314935 |
| GSE9593 | Up | 0.4408546012 |
| GSE43922 | Down | -0.0098757024 |
| GSE24585 | Up | 0.2920361194 |
| GSE37065 | Down | -0.0881944667 |
| GSE28863_A1 | Up | 0.0527831054 |
| GSE28863_A2 | Up | 0.3679061710 |
| GSE28863_A3 | Up | 0.0680190434 |
| GSE28863_A4 | Up | 0.0386519176 |
| GSE48662 | Up | 0.0586714959 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Ribostamycin | DB03615 | EXPT02786 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-210-3p | MIMAT0000267 | MIRT003155 | 2DGE//immunoprecipitaion//Mass spectrometry//Microarray//qRT-PCR//Western blot | Functional MTI | 19826008 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040162 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040772 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042160 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047151 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049210 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
