HCSGD entry for MINK1

1. General information

Official gene symbolMINK1
Entrez ID50488
Gene full namemisshapen-like kinase 1
Other gene symbolsB55 MAP4K6 MINK YSK2 ZC3 hMINK hMINKbeta
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001952Regulation of cell-matrix adhesionIMPbiological_process
GO:0004672Protein kinase activityTASmolecular_function
GO:0004674Protein serine/threonine kinase activityIDA IEAmolecular_function
GO:0004702Receptor signaling protein serine/threonine kinase activityIBAmolecular_function
GO:0005083Small GTPase regulator activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEA ISSmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0006468Protein phosphorylationISSbiological_process
GO:0006950Response to stressISSbiological_process
GO:0007254JNK cascadeIEAbiological_process
GO:0007268Synaptic transmissionISSbiological_process
GO:0007275Multicellular organismal developmentISSbiological_process
GO:0014069Postsynaptic densityIEAcellular_component
GO:0022407Regulation of cell-cell adhesionIMPbiological_process
GO:0030054Cell junctionIEAcellular_component
GO:0030334Regulation of cell migrationIMPbiological_process
GO:0030424AxonIEAcellular_component
GO:0030425DendriteIEAcellular_component
GO:0031532Actin cytoskeleton reorganizationIEA IMPbiological_process
GO:0035556Intracellular signal transductionISSbiological_process
GO:0045060Negative thymic T cell selectionIEAbiological_process
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0046330Positive regulation of JNK cascadeIMPbiological_process
GO:0046777Protein autophosphorylationIDAbiological_process
GO:0048813Dendrite morphogenesisISSbiological_process
GO:2000311Regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activityISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.05674651040.93451731700.51754154541.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1542287726
GSE13712_SHEARDown-0.1507529816
GSE13712_STATICUp0.0466457704
GSE19018Up0.3785848193
GSE19899_A1Up0.1836966964
GSE19899_A2Up0.6302305980
PubMed_21979375_A1Up0.2097207472
PubMed_21979375_A2Up0.9749241764
GSE35957Down-0.0558461203
GSE36640Up0.7246408125
GSE54402Up0.1410881717
GSE9593Up0.1887374416
GSE43922Up0.1759181388
GSE24585Down-0.0953515948
GSE37065Down-0.1409642297
GSE28863_A1Up0.1601164250
GSE28863_A2Down-0.1489895907
GSE28863_A3Down-0.0073821633
GSE28863_A4Down-0.0647565883
GSE48662Up0.1222224211

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1301-3pMIMAT0005797MIRT036060CLASHFunctional MTI (Weak)23622248
hsa-miR-760MIMAT0004957MIRT036771CLASHFunctional MTI (Weak)23622248
hsa-miR-744-5pMIMAT0004945MIRT037477CLASHFunctional MTI (Weak)23622248
hsa-miR-18a-3pMIMAT0002891MIRT040973CLASHFunctional MTI (Weak)23622248
hsa-miR-186-5pMIMAT0000456MIRT045281CLASHFunctional MTI (Weak)23622248
hsa-miR-222-3pMIMAT0000279MIRT046617CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049099CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22665485Misshapen-like kinase 1 (MINK1) is a novel component of striatin-interacting phosphatase and kinase (STRIPAK) and is required for the completion of cytokinesis
22665485Mammalian Misshapen-like kinase 1 (MINK1) is a member of the germinal center kinases and is known to regulate cytoskeletal organization and oncogene-induced cell senescence
22665485To search for novel regulators of cytokinesis, we performed a screen using a library of siRNAs and found that MINK1 was essential for cytokinesis
22665485Mass spectrometry analysis showed that MINK1 was a component of STRIPAK and that MINK1 directly interacted with STRN4
22665485Similar to MINK1 depletion, STRN4-knockdown induced multinucleated cells and inhibited the completion of abscission
22665485In addition, STRN4 reduced MINK1 activity in the presence of catalytic and structural subunits of PP2A
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