HCSGD entry for PNPLA8

1. General information

Official gene symbolPNPLA8
Entrez ID50640
Gene full namepatatin-like phospholipase domain containing 8
Other gene symbolsIPLA2(GAMMA) IPLA2-2 IPLA2G iPLA2gamma
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneIEAcellular_component
GO:0001516Prostaglandin biosynthetic processIDAbiological_process
GO:0004622Lysophospholipase activityIEAmolecular_function
GO:0005524ATP bindingNASmolecular_function
GO:0005622IntracellularIDAcellular_component
GO:0005777PeroxisomeIDAcellular_component
GO:0005778Peroxisomal membraneIDAcellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0006629Lipid metabolic processIEAbiological_process
GO:0006631Fatty acid metabolic processIDAbiological_process
GO:0006644Phospholipid metabolic processTASbiological_process
GO:0008219Cell deathIDAbiological_process
GO:0016020MembraneIDAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016787Hydrolase activityIEAmolecular_function
GO:0019369Arachidonic acid metabolic processIDAbiological_process
GO:0034638Phosphatidylcholine catabolic processIDAbiological_process
GO:0036151Phosphatidylcholine acyl-chain remodelingTASbiological_process
GO:0036152Phosphatidylethanolamine acyl-chain remodelingTASbiological_process
GO:0043651Linoleic acid metabolic processIDAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046338Phosphatidylethanolamine catabolic processIDAbiological_process
GO:0046474Glycerophospholipid biosynthetic processTASbiological_process
GO:0047499Calcium-independent phospholipase A2 activityIDAmolecular_function
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0050482Arachidonic acid secretionIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00315579200.95281474110.15143132971.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.7308114860
GSE13712_SHEARDown-0.0098466111
GSE13712_STATICDown-0.1037870860
GSE19018Up0.2253121028
GSE19899_A1Up1.1202242346
GSE19899_A2Up0.8123204501
PubMed_21979375_A1Up2.1608930330
PubMed_21979375_A2Up0.9750294729
GSE35957Up0.0233241124
GSE36640Up0.6869816087
GSE54402Up0.4733650866
GSE9593Up0.0681457185
GSE43922Up0.7848503437
GSE24585Up0.9022005584
GSE37065Up0.3372741932
GSE28863_A1Down-0.0655857176
GSE28863_A2Up0.3100981194
GSE28863_A3Down-0.6904360009
GSE28863_A4Down-0.3861188380
GSE48662Up0.0197324784

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT020888ProteomicsFunctional MTI (Weak)18668040
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.