HCSGD entry for PCBD1
1. General information
| Official gene symbol | PCBD1 |
|---|---|
| Entrez ID | 5092 |
| Gene full name | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha |
| Other gene symbols | DCOH PCBD PCD PHS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003713 | Transcription coactivator activity | IEA | molecular_function |
| GO:0004505 | Phenylalanine 4-monooxygenase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006559 | L-phenylalanine catabolic process | TAS | biological_process |
| GO:0006729 | Tetrahydrobiopterin biosynthetic process | IEA | biological_process |
| GO:0008124 | 4-alpha-hydroxytetrahydrobiopterin dehydratase activity | EXP | molecular_function |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0043496 | Regulation of protein homodimerization activity | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0051289 | Protein homotetramerization | IEA | biological_process |
| GO:0051291 | Protein heterooligomerization | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1097411079 | 0.4896815205 | 0.6869193103 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1509424918 |
| GSE13712_SHEAR | Up | 0.0117052187 |
| GSE13712_STATIC | Up | 0.1210680294 |
| GSE19018 | Up | 0.2388593997 |
| GSE19899_A1 | Down | -0.2596067102 |
| GSE19899_A2 | Up | 1.3574353751 |
| PubMed_21979375_A1 | Up | 0.2928624994 |
| PubMed_21979375_A2 | Down | -0.1455027734 |
| GSE35957 | Up | 0.1582052949 |
| GSE36640 | Up | 0.4648555589 |
| GSE54402 | Up | 0.1080209926 |
| GSE9593 | Up | 1.0047228697 |
| GSE43922 | Up | 0.0371705589 |
| GSE24585 | Down | -0.4042776925 |
| GSE37065 | Down | -0.0870289994 |
| GSE28863_A1 | Down | -0.3307537827 |
| GSE28863_A2 | Down | -0.2490984928 |
| GSE28863_A3 | Up | 0.0441025246 |
| GSE28863_A4 | Up | 0.0737723556 |
| GSE48662 | Up | 0.0891871841 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| 7,8-Dihydrobiopterin | DB04400 | EXPT01697 | DB03271 | EXPT01698 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-331-3p | MIMAT0000760 | MIRT043343 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 11237869 | Differential expression of chicken dimerization cofactor of hepatocyte nuclear factor-1 (DcoH) and its novel counterpart, DcoHalpha |
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