HCSGD entry for FIS1

1. General information

Official gene symbolFIS1
Entrez ID51024
Gene full namefission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
Other gene symbolsTTC11
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000266Mitochondrial fissionIDA IMPbiological_process
GO:0000422Mitochondrion degradationIDAbiological_process
GO:0001836Release of cytochrome c from mitochondriaIMPbiological_process
GO:0005102Receptor bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005739MitochondrionIDAcellular_component
GO:0005777PeroxisomeIDA ISScellular_component
GO:0005779Integral component of peroxisomal membraneIDAcellular_component
GO:0006626Protein targeting to mitochondrionIMPbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationIMPbiological_process
GO:0008053Mitochondrial fusionIMPbiological_process
GO:0010821Regulation of mitochondrion organizationIMPbiological_process
GO:0016559Peroxisome fissionIDA IMPbiological_process
GO:0031307Integral component of mitochondrial outer membraneIDA NAScellular_component
GO:0032471Negative regulation of endoplasmic reticulum calcium ion concentrationIMPbiological_process
GO:0035584Calcium-mediated signaling using intracellular calcium sourceIMPbiological_process
GO:0043234Protein complexIDAcellular_component
GO:0043280Positive regulation of cysteine-type endopeptidase activity involved in apoptotic processIMPbiological_process
GO:0043653Mitochondrial fragmentation involved in apoptotic processIDA IMPbiological_process
GO:0051260Protein homooligomerizationIMPbiological_process
GO:0051561Positive regulation of mitochondrial calcium ion concentrationIMPbiological_process
GO:0070584Mitochondrion morphogenesisIMPbiological_process
GO:0090141Positive regulation of mitochondrial fissionIDAbiological_process
GO:0090314Positive regulation of protein targeting to membraneIDAbiological_process
GO:2001244Positive regulation of intrinsic apoptotic signaling pathwayIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.49278027430.11875882760.99999024730.6620978642

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.5428908844
GSE13712_SHEARUp0.1840611123
GSE13712_STATICDown-0.0062904064
GSE19018Down-0.1473032963
GSE19899_A1Down-0.0338247229
GSE19899_A2Down-0.0429276470
PubMed_21979375_A1Up0.9490282280
PubMed_21979375_A2Down-0.1733216573
GSE35957Down-0.1395106457
GSE36640Up0.3680107478
GSE54402Up0.1589798045
GSE9593Up0.0565286044
GSE43922Up0.0126780431
GSE24585Down-0.2364404109
GSE37065Down-0.2659956323
GSE28863_A1Down-0.4516009770
GSE28863_A2Down-0.2585994867
GSE28863_A3Down-0.7062954551
GSE28863_A4Down-0.1307491038
GSE48662Up0.0913355413

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-484MIMAT0002174MIRT006714ChIP-seq//Immunoblot//LacZ reporter assay//qRT-PCRFunctional MTI22510686
hsa-miR-505-3pMIMAT0002876MIRT041016CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23907611Human mitochondrial Fis1 links to cell cycle regulators at G2/M transition
23907611Here, we report that enforced mitochondrial elongation by hFis1 depletion caused a severe defect in cell cycle progression through G2/M phase (~3-fold reduction in mitotic index; p < 0
23907611Our findings suggest that mitochondrial fission molecule hFis1 ensures the proper cell division by interplay with the cell cycle machinery
17545159Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence
17545159Using short hairpin RNA, we reduced the expression levels of hFis1 in mammalian cells
17545159Cells lacking hFis1 showed sustained elongation of mitochondria and underwent significant cellular morphological changes, including enlargement, flattening, and increased cellular granularity
17545159In these cells, staining for acidic senescence-associated beta-galactosidase activity was elevated, and the rate of cell proliferation was greatly reduced, indicating that cells lacking hFis1 undergo senescence-associated phenotypic changes
17545159Reintroduction of the hFis1 gene into hFis1-depleted cells restored mitochondrial fragmentation and suppressed senescence-associated beta-galactosidase activity
17545159Moreover, depletion of both hFis1 and OPA1, a critical component of mitochondrial fusion, resulted in extensive mitochondrial fragmentation and markedly rescued cells from senescence-associated phenotypic changes
16883569Formation of elongated giant mitochondria in DFO-induced cellular senescence: involvement of enhanced fusion process through modulation of Fis1
16883569In all senescent progresses employed in this study Fis1 protein, a mitochondrial fission modulator, was commonly downexpressed
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