HCSGD entry for HERC5
1. General information
| Official gene symbol | HERC5 |
|---|---|
| Entrez ID | 51191 |
| Gene full name | HECT and RLD domain containing E3 ubiquitin protein ligase 5 |
| Other gene symbols | CEB1 CEBP1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000079 | Regulation of cyclin-dependent protein serine/threonine kinase activity | TAS | biological_process |
| GO:0004842 | Ubiquitin-protein ligase activity | IBA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IBA | cellular_component |
| GO:0005737 | Cytoplasm | IBA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0032020 | ISG15-protein conjugation | IDA | biological_process |
| GO:0032480 | Negative regulation of type I interferon production | TAS | biological_process |
| GO:0042296 | ISG15 ligase activity | IDA | molecular_function |
| GO:0042787 | Protein ubiquitination involved in ubiquitin-dependent protein catabolic process | IBA | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0050688 | Regulation of defense response to virus | IDA | biological_process |
| GO:0051607 | Defense response to virus | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0026140572 | 0.9274945367 | 0.1384398390 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4821485254 |
| GSE13712_SHEAR | Up | 3.2378908150 |
| GSE13712_STATIC | Up | 2.5973596175 |
| GSE19018 | Up | 0.0222074793 |
| GSE19899_A1 | Up | 0.3266623389 |
| GSE19899_A2 | Up | 0.0795702363 |
| PubMed_21979375_A1 | Up | 0.2375871156 |
| PubMed_21979375_A2 | Down | -0.0705279933 |
| GSE35957 | Down | -2.3871295337 |
| GSE36640 | Up | 0.0766977536 |
| GSE54402 | Up | 0.0599199528 |
| GSE9593 | Down | -0.0638029584 |
| GSE43922 | Up | 0.0912937433 |
| GSE24585 | Up | 1.2229971318 |
| GSE37065 | Up | 1.4132463153 |
| GSE28863_A1 | Down | -0.0862549086 |
| GSE28863_A2 | Up | 1.3597101886 |
| GSE28863_A3 | Up | 0.1475234219 |
| GSE28863_A4 | Up | 0.0743470316 |
| GSE48662 | Up | 0.0446013542 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT023970 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20045429 | On further evaluation of the molecular mechanisms underlying the senescent response, a significant decrease in the expression levels of HERC5 was noted |
| 20045429 | HERC5 is a ubiquitin ligase of the HERC family and is implicated to be involved in innate immune responses to viral and bacterial infections |
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