HCSGD entry for PCYT1A
1. General information
| Official gene symbol | PCYT1A |
|---|---|
| Entrez ID | 5130 |
| Gene full name | phosphate cytidylyltransferase 1, choline, alpha |
| Other gene symbols | CCTA CT CTA CTPCT PCYT1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003824 | Catalytic activity | IEA | molecular_function |
| GO:0004105 | Choline-phosphate cytidylyltransferase activity | IEA ISS | molecular_function |
| GO:0005789 | Endoplasmic reticulum membrane | IEA ISS TAS | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0006644 | Phospholipid metabolic process | TAS | biological_process |
| GO:0006656 | Phosphatidylcholine biosynthetic process | ISS TAS | biological_process |
| GO:0006657 | CDP-choline pathway | ISS | biological_process |
| GO:0008289 | Lipid binding | IEA | molecular_function |
| GO:0009058 | Biosynthetic process | IEA | biological_process |
| GO:0042587 | Glycogen granule | IEA ISS | cellular_component |
| GO:0042803 | Protein homodimerization activity | IEA | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046474 | Glycerophospholipid biosynthetic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0574883895 | 0.9465944417 | 0.5208685293 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0231303704 |
| GSE13712_SHEAR | Up | 0.4715699434 |
| GSE13712_STATIC | Up | 0.3924972277 |
| GSE19018 | Up | 0.0087830536 |
| GSE19899_A1 | Up | 0.0263222693 |
| GSE19899_A2 | Up | 0.4188008323 |
| PubMed_21979375_A1 | Down | -0.2032663704 |
| PubMed_21979375_A2 | Up | 0.1899849840 |
| GSE35957 | Up | 0.1562834873 |
| GSE36640 | Up | 0.9501064136 |
| GSE54402 | Up | 0.2908123706 |
| GSE9593 | Up | 0.6470086279 |
| GSE43922 | Up | 0.1694357731 |
| GSE24585 | Up | 0.1403581482 |
| GSE37065 | Down | -0.0641632697 |
| GSE28863_A1 | Up | 0.1212795925 |
| GSE28863_A2 | Up | 0.2049412175 |
| GSE28863_A3 | Down | -0.6208975245 |
| GSE28863_A4 | Down | -0.2266610490 |
| GSE48662 | Up | 0.2960178644 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Choline | DB00122 | NUTR00020 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT032475 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-26a-5p | MIMAT0000082 | MIRT050150 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
