HCSGD entry for POLK
1. General information
| Official gene symbol | POLK |
|---|---|
| Entrez ID | 51426 |
| Gene full name | polymerase (DNA directed) kappa |
| Other gene symbols | DINB1 DINP POLQ |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003684 | Damaged DNA binding | IEA | molecular_function |
| GO:0003887 | DNA-directed DNA polymerase activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006281 | DNA repair | IEA TAS | biological_process |
| GO:0006297 | Nucleotide-excision repair, DNA gap filling | IMP | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4394963489 | 0.6024578967 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0175627762 |
| GSE13712_SHEAR | Down | -0.0278724586 |
| GSE13712_STATIC | Up | 0.1486905077 |
| GSE19018 | Up | 0.1119812150 |
| GSE19899_A1 | Down | -0.1483130962 |
| GSE19899_A2 | Down | -0.0395827959 |
| PubMed_21979375_A1 | Up | 0.5837959042 |
| PubMed_21979375_A2 | Up | 0.0177733717 |
| GSE35957 | Up | 0.1112996051 |
| GSE36640 | Up | 0.1198054148 |
| GSE54402 | Down | -0.0970470068 |
| GSE9593 | Down | -0.0757235721 |
| GSE43922 | Up | 0.0228168458 |
| GSE24585 | Up | 0.0656610320 |
| GSE37065 | Up | 0.2159141606 |
| GSE28863_A1 | Up | 0.4570263288 |
| GSE28863_A2 | Up | 0.3193562159 |
| GSE28863_A3 | Down | -0.4974678026 |
| GSE28863_A4 | Down | -0.4186985201 |
| GSE48662 | Up | 0.0859933984 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| 1,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENE | DB07435 | - |
| 1-[2-DEOXYRIBOFURANOSYL]-2,4-DIFLUORO-5-METHYL-BENZENE-5'MONOPHOSPHATE | DB07652 | - |
| 2'-deoxy-N-(naphthalen-1-ylmethyl)guanosine 5'-(dihydrogen phosphate) | DB08237 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017418 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-132-3p | MIMAT0000426 | MIRT021743 | Microarray | Functional MTI (Weak) | 17612493 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
