HCSGD entry for PDE6H

1. General information

Official gene symbolPDE6H
Entrez ID5149
Gene full namephosphodiesterase 6H, cGMP-specific, cone, gamma
Other gene symbolsACHM6 RCD3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000187Activation of MAPK activityIEAbiological_process
GO:0004857Enzyme inhibitor activityTASmolecular_function
GO:0007601Visual perceptionIEAbiological_process
GO:0030553CGMP bindingIEAmolecular_function
GO:0043086Negative regulation of catalytic activityTASbiological_process
GO:0045742Positive regulation of epidermal growth factor receptor signaling pathwayIEAbiological_process
GO:0045745Positive regulation of G-protein coupled receptor protein signaling pathwayIEAbiological_process
GO:00475553',5'-cyclic-GMP phosphodiesterase activityIEAmolecular_function
GO:0050896Response to stimulusIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.48640333570.88069419470.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0775181116
GSE13712_SHEARDown-0.0056685732
GSE13712_STATICDown-0.1387097617
GSE19018Up0.2351974685
GSE19899_A1Up0.1312065875
GSE19899_A2Down-0.0419376294
PubMed_21979375_A1Up0.2820279171
PubMed_21979375_A2Up0.4667192358
GSE35957Up0.1532383511
GSE36640Up0.0725675576
GSE54402Up0.0456263796
GSE9593Down-0.0079683944
GSE43922Up0.0106324793
GSE24585Down-0.0004654982
GSE37065Up0.1311279980
GSE28863_A1Down-0.1091994602
GSE28863_A2Down-0.1592610886
GSE28863_A3Up0.1012916520
GSE28863_A4Down-0.0613305747
GSE48662Up0.0443537558

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

SildenafilDB00203 APRD00556
VardenafilDB00862 APRD00699

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017528MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.