HCSGD entry for DTL
1. General information
| Official gene symbol | DTL |
|---|---|
| Entrez ID | 51514 |
| Gene full name | denticleless E3 ubiquitin protein ligase homolog (Drosophila) |
| Other gene symbols | CDT2 DCAF2 L2DTL RAMP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000209 | Protein polyubiquitination | IDA TAS | biological_process |
| GO:0004842 | Ubiquitin-protein ligase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005694 | Chromosome | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0006260 | DNA replication | IEA | biological_process |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IDA TAS | biological_process |
| GO:0006513 | Protein monoubiquitination | IDA | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IDA | biological_process |
| GO:0009411 | Response to UV | IDA | biological_process |
| GO:0019985 | Translesion synthesis | IDA | biological_process |
| GO:0031464 | Cul4A-RING ubiquitin ligase complex | IDA | cellular_component |
| GO:0031465 | Cul4B-RING ubiquitin ligase complex | IDA | cellular_component |
| GO:0031572 | G2 DNA damage checkpoint | IMP | biological_process |
| GO:0031965 | Nuclear membrane | IEA | cellular_component |
| GO:0051726 | Regulation of cell cycle | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9406750845 | 0.0000101516 | 0.9999902473 | 0.0069833333 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.9438469624 |
| GSE13712_SHEAR | Down | -0.5863410171 |
| GSE13712_STATIC | Down | -0.5735516591 |
| GSE19018 | Down | -0.4343815979 |
| GSE19899_A1 | Down | -1.6218904528 |
| GSE19899_A2 | Down | -4.5752702013 |
| PubMed_21979375_A1 | Down | -1.6025119649 |
| PubMed_21979375_A2 | Down | -5.4539391550 |
| GSE35957 | Down | -4.3886402897 |
| GSE36640 | Down | -4.2645155841 |
| GSE54402 | Down | -0.3040483296 |
| GSE9593 | Down | -2.1999943825 |
| GSE43922 | Down | -2.7661268239 |
| GSE24585 | Up | 0.5142238218 |
| GSE37065 | Down | -0.9349243747 |
| GSE28863_A1 | Down | -0.7644642672 |
| GSE28863_A2 | Up | 1.7095355739 |
| GSE28863_A3 | Down | -0.6459109979 |
| GSE28863_A4 | Down | -0.1074294217 |
| GSE48662 | Down | -1.7382598100 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-30a-5p | MIMAT0000087 | MIRT006563 | Flow//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22287560 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT004848 | Luciferase reporter assay//qRT-PCR//Reporter assay;Microarray;Other | Functional MTI | 19074876 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024273 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030300 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030601 | Microarray | Functional MTI (Weak) | 19748357 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049694 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
