HCSGD entry for PDGFB

1. General information

Official gene symbolPDGFB
Entrez ID5155
Gene full nameplatelet-derived growth factor beta polypeptide
Other gene symbolsPDGF-2 PDGF2 SIS SSV c-sis
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneTAScellular_component
GO:0001666Response to hypoxiaIEAbiological_process
GO:0001892Embryonic placenta developmentIEA ISSbiological_process
GO:0001938Positive regulation of endothelial cell proliferationIDA IEAbiological_process
GO:0002548Monocyte chemotaxisIDAbiological_process
GO:0002576Platelet degranulationTASbiological_process
GO:0003104Positive regulation of glomerular filtrationIEA ISSbiological_process
GO:0005161Platelet-derived growth factor receptor bindingIDA IEA IPI NASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005518Collagen bindingIDAmolecular_function
GO:0005576Extracellular regionNAS TAScellular_component
GO:0005615Extracellular spaceIBAcellular_component
GO:0005737CytoplasmIEA ISScellular_component
GO:0005788Endoplasmic reticulum lumenTAScellular_component
GO:0006260DNA replicationIEAbiological_process
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006929Substrate-dependent cell migrationIEAbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayIEA ISSbiological_process
GO:0007507Heart developmentIEA ISSbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008083Growth factor activityIDA IEAmolecular_function
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0009611Response to woundingIDA NASbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0010512Negative regulation of phosphatidylinositol biosynthetic processIDAbiological_process
GO:0010544Negative regulation of platelet activationIDAbiological_process
GO:0014068Positive regulation of phosphatidylinositol 3-kinase signalingIDAbiological_process
GO:0014911Positive regulation of smooth muscle cell migrationIDA IEAbiological_process
GO:0016049Cell growthIEAbiological_process
GO:0016176Superoxide-generating NADPH oxidase activator activityIDAmolecular_function
GO:0016323Basolateral plasma membraneIEA ISScellular_component
GO:0018105Peptidyl-serine phosphorylationIDAbiological_process
GO:0018108Peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0030031Cell projection assemblyIEAbiological_process
GO:0030036Actin cytoskeleton organizationIEAbiological_process
GO:0030097HemopoiesisIMPbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030335Positive regulation of cell migrationIDAbiological_process
GO:0030336Negative regulation of cell migrationIEAbiological_process
GO:0031093Platelet alpha granule lumenTAScellular_component
GO:0031954Positive regulation of protein autophosphorylationIDAbiological_process
GO:0032147Activation of protein kinase activityIDAbiological_process
GO:0032148Activation of protein kinase B activityIDAbiological_process
GO:0032355Response to estradiolIEAbiological_process
GO:0032868Response to insulinIEAbiological_process
GO:0035793Positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathwayIDAbiological_process
GO:0038001Paracrine signalingIEA ISSbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0042056Chemoattractant activityIDAmolecular_function
GO:0042060Wound healingIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0043406Positive regulation of MAP kinase activityIDA IEAbiological_process
GO:0043410Positive regulation of MAPK cascadeIMPbiological_process
GO:0043536Positive regulation of blood vessel endothelial cell migrationIDAbiological_process
GO:0043552Positive regulation of phosphatidylinositol 3-kinase activityIDAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045737Positive regulation of cyclin-dependent protein kinase activityIDAbiological_process
GO:0045740Positive regulation of DNA replicationIDAbiological_process
GO:0045743Positive regulation of fibroblast growth factor receptor signaling pathwayIEAbiological_process
GO:0045840Positive regulation of mitosisIDAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA IEAbiological_process
GO:0046982Protein heterodimerization activityIPImolecular_function
GO:0048008Platelet-derived growth factor receptor signaling pathwayIDA IEAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0048146Positive regulation of fibroblast proliferationIDAbiological_process
GO:0048407Platelet-derived growth factor bindingIPImolecular_function
GO:0048514Blood vessel morphogenesisIEAbiological_process
GO:0048661Positive regulation of smooth muscle cell proliferationIDA IEAbiological_process
GO:0050730Regulation of peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0050918Positive chemotaxisIDAbiological_process
GO:0050921Positive regulation of chemotaxisIDAbiological_process
GO:0051781Positive regulation of cell divisionIEAbiological_process
GO:0060326Cell chemotaxisIDAbiological_process
GO:0060445Branching involved in salivary gland morphogenesisIEAbiological_process
GO:0060664Epithelial cell proliferation involved in salivary gland morphogenesisIEAbiological_process
GO:0061098Positive regulation of protein tyrosine kinase activityIDAbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0071363Cellular response to growth factor stimulusIDAbiological_process
GO:0071506Cellular response to mycophenolic acidIEA ISSbiological_process
GO:0072126Positive regulation of glomerular mesangial cell proliferationIDAbiological_process
GO:0072255Metanephric glomerular mesangial cell developmentIEA ISSbiological_process
GO:0072262Metanephric glomerular mesangial cell proliferation involved in metanephros developmentIEAbiological_process
GO:0072264Metanephric glomerular endothelium developmentIEAbiological_process
GO:0072593Reactive oxygen species metabolic processIMPbiological_process
GO:0090280Positive regulation of calcium ion importIDAbiological_process
GO:1900127Positive regulation of hyaluronan biosynthetic processIDAbiological_process
GO:2000379Positive regulation of reactive oxygen species metabolic processIDAbiological_process
GO:2000573Positive regulation of DNA biosynthetic processIDAbiological_process
GO:2000591Positive regulation of metanephric mesenchymal cell migrationIDA IEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.42726607270.94500203640.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0078347937
GSE13712_SHEARUp0.0843399916
GSE13712_STATICDown-0.0750658915
GSE19018Down-0.0499280320
GSE19899_A1Up0.0359283919
GSE19899_A2Up0.1840642084
PubMed_21979375_A1Up0.0081555243
PubMed_21979375_A2Up0.0506998239
GSE35957Up0.2091115993
GSE36640Up0.1417408854
GSE54402Up0.0541838480
GSE9593Up0.0332275494
GSE43922Up0.0544459175
GSE24585Up0.0392748130
GSE37065Down-0.0426826207
GSE28863_A1Down-0.0015147776
GSE28863_A2Up0.0631563839
GSE28863_A3Up0.3343108287
GSE28863_A4Up0.1886911693
GSE48662Down-0.0536711071

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-146b-3pMIMAT0004766MIRT005548ELISA//Immunoblot//Microarray//qRT-PCRFunctional MTI (Weak)21266476
hsa-miR-26b-5pMIMAT0000083MIRT029444MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23934686Platelet-derived growth factor B induces senescence and transformation in normal human fibroblasts
23934686Here we show that normal human dermal fibroblasts display a complex response to Platelet derived growth factor B (PDGFB) expression
23934686Indeed, PDGFB expression induces, in the same cell population, both senescence and cellular transformation
23934686This senescence state is p53 dependent as inhibiting the p53 pathway blocks the ability of PDGFB to induce senescence and results in strong cellular transformation increase upon PDGFB expression
23934686The relevance of these observations is supported by the fact that human dermatofibrosarcoma protuberans, skin tumors arising from constitutive PDGFB production with little aggressiveness, also display some senescence hallmarks
23934686Together these data support the view that PDGFB, a mitogenic growth factor, has a limited ability to induce senescence
19219070Sox5 was identified as a brain tumor locus in a retroviral insertional mutagenesis screen of platelet-derived growth factor B (PDGFB)-induced mouse gliomas
19219070Combined expression of Sox5 and PDGFB in primary brain cell cultures caused decreased proliferation and an increased number of senescent cells in the Ink4a-/- cells only
19219070Protein analyses showed a reduction in the amount and activation of Akt and increased levels of p27(Kip1) upon Sox5 expression that was dominant to PDGFB signaling and specific to Ink4a-/- cells
19219070Our data suggest a novel pathway, where Sox5 may suppress the oncogenic effects of PDGFB signaling during glioma development by regulating p27(Kip1) in a p19(Arf)-dependent manner, leading to acute cellular senescence
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