HCSGD entry for IL23A

1. General information

Official gene symbolIL23A
Entrez ID51561
Gene full nameinterleukin 23, alpha subunit p19
Other gene symbolsIL-23 IL-23A IL23P19 P19 SGRF
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001916Positive regulation of T cell mediated cytotoxicityISSbiological_process
GO:0002230Positive regulation of defense response to virus by hostIDA ISSbiological_process
GO:0002827Positive regulation of T-helper 1 type immune responseIDA ISS NAS TASbiological_process
GO:0005125Cytokine activityIEAmolecular_function
GO:0006954Inflammatory responseIEAbiological_process
GO:0010535Positive regulation of activation of JAK2 kinase activityIDAbiological_process
GO:0032693Negative regulation of interleukin-10 productionIMPbiological_process
GO:0032725Positive regulation of granulocyte macrophage colony-stimulating factor productionIDAbiological_process
GO:0032729Positive regulation of interferon-gamma productionIDA TASbiological_process
GO:0032733Positive regulation of interleukin-10 productionIDA TASbiological_process
GO:0032735Positive regulation of interleukin-12 productionIDAbiological_process
GO:0032740Positive regulation of interleukin-17 productionIDAbiological_process
GO:0032760Positive regulation of tumor necrosis factor productionIMPbiological_process
GO:0032816Positive regulation of natural killer cell activationICbiological_process
GO:0032819Positive regulation of natural killer cell proliferationIDAbiological_process
GO:0034105Positive regulation of tissue remodelingICbiological_process
GO:0042098T cell proliferationIEAbiological_process
GO:0042102Positive regulation of T cell proliferationIDAbiological_process
GO:0042104Positive regulation of activated T cell proliferationIDAbiological_process
GO:0042346Positive regulation of NF-kappaB import into nucleusTASbiological_process
GO:0042510Regulation of tyrosine phosphorylation of Stat1 proteinIDAbiological_process
GO:0042517Positive regulation of tyrosine phosphorylation of Stat3 proteinIDAbiological_process
GO:0042520Positive regulation of tyrosine phosphorylation of Stat4 proteinIDAbiological_process
GO:0042523Positive regulation of tyrosine phosphorylation of Stat5 proteinIDAbiological_process
GO:0043382Positive regulation of memory T cell differentiationISSbiological_process
GO:0045087Innate immune responseIEAbiological_process
GO:0045519Interleukin-23 receptor bindingIDAmolecular_function
GO:0045672Positive regulation of osteoclast differentiationIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0048771Tissue remodelingIEAbiological_process
GO:0050729Positive regulation of inflammatory responseICbiological_process
GO:0050829Defense response to Gram-negative bacteriumIDAbiological_process
GO:0051135Positive regulation of NK T cell activationIC IDAbiological_process
GO:0051142Positive regulation of NK T cell proliferationIDAbiological_process
GO:0051607Defense response to virusIEAbiological_process
GO:0070743Interleukin-23 complexIDAcellular_component
GO:0090023Positive regulation of neutrophil chemotaxisIEAbiological_process
GO:2000318Positive regulation of T-helper 17 type immune responseISSbiological_process
GO:2000330Positive regulation of T-helper 17 cell lineage commitmentISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.62378977240.78500718060.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0647871695
GSE13712_SHEARUp0.0233665090
GSE13712_STATICDown-0.0206950997
GSE19018Down-0.0005278593
GSE19899_A1Up0.0588656492
GSE19899_A2Up0.0777417311
PubMed_21979375_A1Down-0.0337303814
PubMed_21979375_A2Up0.0244848918
GSE35957Down-0.0204860300
GSE36640Up0.0091626717
GSE54402Up0.1606963076
GSE9593Up0.0597287826
GSE43922Up0.4921039500
GSE24585Up0.2349285775
GSE37065Down-0.2311614183
GSE28863_A1Down-0.0895359218
GSE28863_A2Down-0.0945881325
GSE28863_A3Up0.0582223820
GSE28863_A4Down-0.1079716389
GSE48662Up0.0045865696

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

BriakinumabDB05459 -
UstekinumabDB05679 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25466460The SPR biosensor also shows specificity for IGFBP7 compared to that for biologically relevant interleukin (IL) derivatives including IL4, IL23, IL29, and IFG1
22156197Recent studies indicate that clearance of senescent neutrophils by resident tissue macrophages and DCs helps to set homeostatic levels of neutrophils via effects on the IL-23/IL-17/G-CSF cytokine axis, which stimulates neutrophil production in the bone marrow
22156197Furthermore, activation of LXR by engulfed neutrophils directly repressed the IL-23/IL-17/G-CSF granulopoietic cytokine cascade
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