HCSGD entry for PDHA1
1. General information
| Official gene symbol | PDHA1 |
|---|---|
| Entrez ID | 5160 |
| Gene full name | pyruvate dehydrogenase (lipoamide) alpha 1 |
| Other gene symbols | PDHA PDHCE1A PHE1A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004738 | Pyruvate dehydrogenase activity | IDA IEA | molecular_function |
| GO:0004739 | Pyruvate dehydrogenase (acetyl-transferring) activity | IEA | molecular_function |
| GO:0005739 | Mitochondrion | IEA TAS | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0006086 | Acetyl-CoA biosynthetic process from pyruvate | IDA | biological_process |
| GO:0006090 | Pyruvate metabolic process | TAS | biological_process |
| GO:0006096 | Glycolysis | IEA | biological_process |
| GO:0006099 | Tricarboxylic acid cycle | IDA | biological_process |
| GO:0010510 | Regulation of acetyl-CoA biosynthetic process from pyruvate | TAS | biological_process |
| GO:0016624 | Oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor | IEA | molecular_function |
| GO:0044237 | Cellular metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045254 | Pyruvate dehydrogenase complex | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9832291212 | 0.0115271038 | 0.9999902473 | 0.2125289510 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0104035305 |
| GSE13712_SHEAR | Down | -0.0606068077 |
| GSE13712_STATIC | Up | 0.1473935360 |
| GSE19018 | Down | -0.0532312499 |
| GSE19899_A1 | Down | -0.7375148672 |
| GSE19899_A2 | Down | -0.4801689460 |
| PubMed_21979375_A1 | Down | -0.6925362774 |
| PubMed_21979375_A2 | Down | -0.7730156052 |
| GSE35957 | Down | -0.7383626200 |
| GSE36640 | Down | -0.0750183628 |
| GSE54402 | Down | -0.0450444497 |
| GSE9593 | Down | -0.3416839357 |
| GSE43922 | Down | -0.4294871504 |
| GSE24585 | Down | -0.5829128765 |
| GSE37065 | Down | -0.0360398361 |
| GSE28863_A1 | Up | 0.0192170185 |
| GSE28863_A2 | Up | 0.1324561004 |
| GSE28863_A3 | Down | -0.2656459796 |
| GSE28863_A4 | Down | -0.3049002335 |
| GSE48662 | Down | -0.2939692952 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-22-3p | MIMAT0000077 | MIRT030647 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037151 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-130b-5p | MIMAT0004680 | MIRT038319 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-326 | MIMAT0000756 | MIRT043636 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-191-5p | MIMAT0000440 | MIRT045791 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
