HCSGD entry for ACSL5
1. General information
| Official gene symbol | ACSL5 |
|---|---|
| Entrez ID | 51703 |
| Gene full name | acyl-CoA synthetase long-chain family member 5 |
| Other gene symbols | ACS2 ACS5 FACL5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001676 | Long-chain fatty acid metabolic process | IDA | biological_process |
| GO:0004467 | Long-chain fatty acid-CoA ligase activity | IDA IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005741 | Mitochondrial outer membrane | IEA | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | IEA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016874 | Ligase activity | IEA | molecular_function |
| GO:0019432 | Triglyceride biosynthetic process | TAS | biological_process |
| GO:0035338 | Long-chain fatty-acyl-CoA biosynthetic process | TAS | biological_process |
| GO:0044255 | Cellular lipid metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:2001236 | Regulation of extrinsic apoptotic signaling pathway | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0008047833 | 0.9204740549 | 0.0793359551 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.5073642199 |
| GSE13712_SHEAR | Up | 0.3878729454 |
| GSE13712_STATIC | Up | 0.7770453253 |
| GSE19018 | Down | -0.0534297335 |
| GSE19899_A1 | Up | 0.4148061768 |
| GSE19899_A2 | Up | 3.1424437152 |
| PubMed_21979375_A1 | Up | 3.3411984599 |
| PubMed_21979375_A2 | Up | 3.5088030713 |
| GSE35957 | Down | -0.3964762904 |
| GSE36640 | Up | 0.6791447650 |
| GSE54402 | Up | 1.1243787232 |
| GSE9593 | Down | -0.4760832899 |
| GSE43922 | Up | 1.2805805409 |
| GSE24585 | Down | -0.0919357963 |
| GSE37065 | Up | 0.5650134335 |
| GSE28863_A1 | Up | 0.0638620966 |
| GSE28863_A2 | Down | -0.2847000280 |
| GSE28863_A3 | Up | 0.1068532764 |
| GSE28863_A4 | Up | 0.0132644248 |
| GSE48662 | Down | -0.3149169878 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT019161 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT022047 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT023184 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
