HCSGD entry for RTEL1
1. General information
| Official gene symbol | RTEL1 |
|---|---|
| Entrez ID | 51750 |
| Gene full name | regulator of telomere elongation helicase 1 |
| Other gene symbols | C20orf41 DKCB5 NHL RTEL bK3184A7.3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000723 | Telomere maintenance | IMP ISS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0004003 | ATP-dependent DNA helicase activity | IEA IMP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA IMP | molecular_function |
| GO:0005634 | Nucleus | IEA ISS | cellular_component |
| GO:0006200 | ATP catabolic process | IMP | biological_process |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0010569 | Regulation of double-strand break repair via homologous recombination | IMP | biological_process |
| GO:0032508 | DNA duplex unwinding | IMP | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0051539 | 4 iron, 4 sulfur cluster binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9441603776 | 0.4057957486 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0037019273 |
| GSE13712_SHEAR | Up | 0.1550171352 |
| GSE13712_STATIC | Down | -0.1689285945 |
| GSE19018 | Down | -0.1385146389 |
| GSE19899_A1 | Down | -0.1373136280 |
| GSE19899_A2 | Down | -0.2934913123 |
| PubMed_21979375_A1 | Up | 0.3393864244 |
| PubMed_21979375_A2 | Down | -0.0876305343 |
| GSE35957 | Down | -0.1326487668 |
| GSE36640 | Down | -0.0113658962 |
| GSE54402 | Up | 0.0938277856 |
| GSE9593 | Down | -0.0316157911 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.4345029036 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-615-3p | MIMAT0003283 | MIRT040125 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 11063723 | Our study shows clearly that TRF1 has a novel physiological significance distinct from its role as a regulator of telomere length in the endogenous chromosome |
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