HCSGD entry for PF4

1. General information

Official gene symbolPF4
Entrez ID5196
Gene full nameplatelet factor 4
Other gene symbolsCXCL4 PF-4 SCYB4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002576Platelet degranulationTASbiological_process
GO:0005576Extracellular regionIC NAS TAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0006955Immune responseIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008009Chemokine activityTASmolecular_function
GO:0008201Heparin bindingIDAmolecular_function
GO:0010628Positive regulation of gene expressionIDAbiological_process
GO:0010744Positive regulation of macrophage derived foam cell differentiationIDAbiological_process
GO:0016525Negative regulation of angiogenesisIDAbiological_process
GO:0019221Cytokine-mediated signaling pathwayIDAbiological_process
GO:0030168Platelet activationIDA TASbiological_process
GO:0030595Leukocyte chemotaxisIDAbiological_process
GO:0030816Positive regulation of cAMP metabolic processIDAbiological_process
GO:0031093Platelet alpha granule lumenTAScellular_component
GO:0032760Positive regulation of tumor necrosis factor productionIDAbiological_process
GO:0042127Regulation of cell proliferationIDAbiological_process
GO:0043950Positive regulation of cAMP-mediated signalingIDAbiological_process
GO:0045347Negative regulation of MHC class II biosynthetic processIDAbiological_process
GO:0045651Positive regulation of macrophage differentiationIDAbiological_process
GO:0045653Negative regulation of megakaryocyte differentiationIDAbiological_process
GO:0045918Negative regulation of cytolysisIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0048248CXCR3 chemokine receptor bindingIDAmolecular_function
GO:2001240Negative regulation of extrinsic apoptotic signaling pathway in absence of ligandIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.03782469890.94538726490.43896997351.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.6578011225
GSE13712_SHEARDown-0.0430473222
GSE13712_STATICDown-0.0732317156
GSE19018Down-0.0167049972
GSE19899_A1Up0.4067778425
GSE19899_A2Up1.2769858944
PubMed_21979375_A1Up0.8811261949
PubMed_21979375_A2Up0.6091240799
GSE35957Up0.0751015290
GSE36640Up0.0364931283
GSE54402Up0.1806557193
GSE9593Down-0.4184925424
GSE43922Up0.1773209804
GSE24585Up0.0207291856
GSE37065Up0.0419553881
GSE28863_A1Up0.1157470223
GSE28863_A2Up0.1029870210
GSE28863_A3Up0.0555149846
GSE28863_A4Up0.0342467944
GSE48662Down-0.1658009444

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.