HCSGD entry for PFKFB3
1. General information
| Official gene symbol | PFKFB3 |
|---|---|
| Entrez ID | 5209 |
| Gene full name | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 |
| Other gene symbols | IPFK2 PFK2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003824 | Catalytic activity | IEA | molecular_function |
| GO:0003873 | 6-phosphofructo-2-kinase activity | IEA NAS | molecular_function |
| GO:0004331 | Fructose-2,6-bisphosphate 2-phosphatase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | TAS | biological_process |
| GO:0006000 | Fructose metabolic process | IEA | biological_process |
| GO:0006003 | Fructose 2,6-bisphosphate metabolic process | IEA | biological_process |
| GO:0006006 | Glucose metabolic process | TAS | biological_process |
| GO:0006096 | Glycolysis | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046835 | Carbohydrate phosphorylation | NAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0326581133 | 0.6525952243 | 0.4168364341 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.8679851821 |
| GSE13712_SHEAR | Up | 1.0218240740 |
| GSE13712_STATIC | Up | 0.6872173050 |
| GSE19018 | Down | -0.0122164544 |
| GSE19899_A1 | Up | 0.0574886042 |
| GSE19899_A2 | Up | 0.3512974797 |
| PubMed_21979375_A1 | Up | 0.6700938031 |
| PubMed_21979375_A2 | Up | 0.1360021952 |
| GSE35957 | Down | -1.3879641900 |
| GSE36640 | Up | 0.1224960654 |
| GSE54402 | Up | 0.1302821763 |
| GSE9593 | Up | 0.1119015342 |
| GSE43922 | Up | 0.1904781629 |
| GSE24585 | Up | 0.2290875470 |
| GSE37065 | Up | 0.3476965984 |
| GSE28863_A1 | Up | 0.1833387646 |
| GSE28863_A2 | Up | 0.6398381743 |
| GSE28863_A3 | Up | 0.1461791520 |
| GSE28863_A4 | Down | -0.2141662671 |
| GSE48662 | Up | 0.3636467900 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028775 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-330-3p | MIMAT0000751 | MIRT043840 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
