HCSGD entry for SERPINB5
1. General information
| Official gene symbol | SERPINB5 |
|---|---|
| Entrez ID | 5268 |
| Gene full name | serpin peptidase inhibitor, clade B (ovalbumin), member 5 |
| Other gene symbols | PI5 maspin |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002009 | Morphogenesis of an epithelium | IEA | biological_process |
| GO:0004867 | Serine-type endopeptidase inhibitor activity | IBA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0006928 | Cellular component movement | TAS | biological_process |
| GO:0010951 | Negative regulation of endopeptidase activity | IBA | biological_process |
| GO:0030162 | Regulation of proteolysis | IBA | biological_process |
| GO:0030198 | Extracellular matrix organization | IEA | biological_process |
| GO:0050678 | Regulation of epithelial cell proliferation | IEA | biological_process |
| GO:0060512 | Prostate gland morphogenesis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5991547624 | 0.7240673493 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0150116721 |
| GSE13712_SHEAR | Down | -0.1402287154 |
| GSE13712_STATIC | Up | 0.2975587659 |
| GSE19018 | Up | 0.1438077671 |
| GSE19899_A1 | Up | 0.1674763470 |
| GSE19899_A2 | Up | 0.0388106394 |
| PubMed_21979375_A1 | Up | 0.1393820799 |
| PubMed_21979375_A2 | Down | -0.0447483814 |
| GSE35957 | Up | 0.0323754471 |
| GSE36640 | Up | 0.0083323459 |
| GSE54402 | Down | -0.0158870954 |
| GSE9593 | Up | 0.0287314338 |
| GSE43922 | Up | 0.0657126445 |
| GSE24585 | Down | -0.1066922753 |
| GSE37065 | Up | 0.1165189993 |
| GSE28863_A1 | Up | 0.0440730640 |
| GSE28863_A2 | Down | -0.1974862287 |
| GSE28863_A3 | Up | 0.0153089803 |
| GSE28863_A4 | Down | -0.1946656664 |
| GSE48662 | Down | -0.0409013876 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| S,S-(2-Hydroxyethyl)Thiocysteine | DB04530 | EXPT00954 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT002776 | Microarray//Microarray;Other | Functional MTI (Weak) | 15685193 |
| hsa-miR-1 | MIMAT0000416 | MIRT002776 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT003567 | Luciferase reporter assay//Western blot | Functional MTI | 18270520 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT003567 | Luciferase reporter assay | Functional MTI | 19253296 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT003567 | Reporter assay;Western blot;qRT-PCR | Functional MTI | 21636785 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT003567 | Reporter assay | Functional MTI | 20693317 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017272 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028408 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029183 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031536 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | NA | hsa-miR-1 | 15685193 | |||
| hsa-miR-21-5p | MIMAT0000076 | 1 | hsa-miR-21 | {Western blot} | {underexpression by 2'-O-Me antisense miRNA oligonucleotides} | 18270520 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22783442 | The expression of cyclin D1, Rb, maspin, p53 and mouse double minute 2 (MDM2) was analyzed in 20 paraffin-embedded tissue samples of normal oral mucosa (NOM), 14 samples of oral leukoplakia without dysplasia (OLD-), 11 samples of leukoplakia with dysplasia (OLD+) and 15 samples of oral squamous cell carcinoma (OSCC) by immunohistochemistry in tissue arrays |
| 22783442 | These findings may indicate a role for cellular senescence in oral carcinogenesis, considering maspin as a reliable senescence marker and prognostic factor in oral premalignant lesions |
| 15126325 | Tumor suppressor maspin is up-regulated during keratinocyte senescence, exerting a paracrine antiangiogenic activity |
| 15126325 | Senescent KC cultures showed a strong increase in mRNA and protein expression of maspin, a member of serine protease inhibitor family and an epithelial cell tumor suppressor with anti-invasive and antiangiogenic activities |
| 15126325 | Immunohistochemical analysis of 14 normal human skin samples (age range from 3 months to 84 years) showed that maspin is expressed by KCs in vivo and that the extent and intensity of maspin expression in the skin is significantly (P = 0 |
| 15126325 | Antiangiogenic activity of maspin secreted by senescent KCs was investigated in vitro by testing the effect of conditioned media from different KC cultures on endothelial cell migration in the presence or absence of several angiogenic factors |
| 15126325 | Neutralizing antibody against maspin abrogated this effect of conditioned media |
| 15126325 | These findings indicate that senescent KCs exert a paracrine antiangiogenic activity, and maspin is the principal contributor to this potentially tumor-suppressive effect of cellular senescence |
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