HCSGD entry for SOX18

1. General information

Official gene symbolSOX18
Entrez ID54345
Gene full nameSRY (sex determining region Y)-box 18
Other gene symbolsHLTS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0000790Nuclear chromatinIDAcellular_component
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIDAmolecular_function
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIDAmolecular_function
GO:0001525AngiogenesisIEPbiological_process
GO:0001570VasculogenesisISSbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001942Hair follicle developmentIEAbiological_process
GO:0001944Vasculature developmentISSbiological_process
GO:0001946LymphangiogenesisIMPbiological_process
GO:0001947Heart loopingISSbiological_process
GO:0003151Outflow tract morphogenesisISSbiological_process
GO:0005634NucleusIDAcellular_component
GO:0022405Hair cycle processIMPbiological_process
GO:0035050Embryonic heart tube developmentISSbiological_process
GO:0042789MRNA transcription from RNA polymerase II promoterIDAbiological_process
GO:0043534Blood vessel endothelial cell migrationIEPbiological_process
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045892Negative regulation of transcription, DNA-templatedISSbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0048469Cell maturationIEAbiological_process
GO:0048866Stem cell fate specificationIEAbiological_process
GO:0060214Endocardium formationISSbiological_process
GO:0060836Lymphatic endothelial cell differentiationISSbiological_process
GO:0060956Endocardial cell differentiationISSbiological_process
GO:0061028Establishment of endothelial barrierIMPbiological_process
GO:0072091Regulation of stem cell proliferationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.63641248810.13139136810.99999024730.6983748384

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0259618346
GSE13712_SHEARDown-1.7103569991
GSE13712_STATICDown-1.8531702877
GSE19018Up0.1228137871
GSE19899_A1Down-0.1323049953
GSE19899_A2Down-0.0441823516
PubMed_21979375_A1Down-0.0412689375
PubMed_21979375_A2Down-0.1153212202
GSE35957Down-0.0962304568
GSE36640Up0.0512143903
GSE54402Down-0.0091882711
GSE9593Down-0.1437299155
GSE43922Up0.1770583861
GSE24585Up0.2266368318
GSE37065Down-0.0421654788
GSE28863_A1Down-0.1700178222
GSE28863_A2Down-0.0549134525
GSE28863_A3Up0.5374474411
GSE28863_A4Up0.1246231626
GSE48662Up0.0000933386

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018859MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.