HCSGD entry for POLR2L

1. General information

Official gene symbolPOLR2L
Entrez ID5441
Gene full namepolymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
Other gene symbolsRBP10 RPABC5 RPB10 RPB10beta RPB7.6 hRPB7.6
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000398MRNA splicing, via spliceosomeTASbiological_process
GO:0001054RNA polymerase I activityIBAmolecular_function
GO:0001055RNA polymerase II activityIBAmolecular_function
GO:0001056RNA polymerase III activityIBAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0003899DNA-directed RNA polymerase activityTASmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005665DNA-directed RNA polymerase II, core complexIDAcellular_component
GO:0005666DNA-directed RNA polymerase III complexIBAcellular_component
GO:0005736DNA-directed RNA polymerase I complexIBAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006281DNA repairTASbiological_process
GO:0006283Transcription-coupled nucleotide-excision repairTASbiological_process
GO:0006289Nucleotide-excision repairTASbiological_process
GO:0006356Regulation of transcription from RNA polymerase I promoterTASbiological_process
GO:0006360Transcription from RNA polymerase I promoterIBAbiological_process
GO:0006366Transcription from RNA polymerase II promoterIDA TASbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0006368Transcription elongation from RNA polymerase II promoterTASbiological_process
GO:00063707-methylguanosine mRNA cappingTASbiological_process
GO:0006383Transcription from RNA polymerase III promoterTASbiological_process
GO:0006385Transcription elongation from RNA polymerase III promoterTASbiological_process
GO:0006386Termination of RNA polymerase III transcriptionTASbiological_process
GO:0008270Zinc ion bindingIBAmolecular_function
GO:0008380RNA splicingTASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016032Viral processTASbiological_process
GO:0032481Positive regulation of type I interferon productionTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0050434Positive regulation of viral transcriptionTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.04629496980.91096821930.47729819891.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3747430819
GSE13712_SHEARUp0.2671437586
GSE13712_STATICUp0.2335400417
GSE19018Down-0.1033931985
GSE19899_A1Down-0.0622131504
GSE19899_A2Up0.8399806321
PubMed_21979375_A1Up0.7015454261
PubMed_21979375_A2Up0.5612252920
GSE35957Up0.1492135122
GSE36640Up0.8766102983
GSE54402Up0.1249274396
GSE9593Up0.7440780579
GSE43922Up0.0021784413
GSE24585Up0.1430102553
GSE37065Down-0.3591049441
GSE28863_A1Down-0.2336599205
GSE28863_A2Down-0.1676118227
GSE28863_A3Up0.2478935059
GSE28863_A4Up0.0055462754
GSE48662Up0.0864960394

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022925Proteomics;MicroarrayFunctional MTI (Weak)18668037
hsa-let-7b-5pMIMAT0000063MIRT032392ProteomicsFunctional MTI (Weak)18668040
hsa-miR-744-5pMIMAT0004945MIRT037575CLASHFunctional MTI (Weak)23622248
hsa-miR-423-3pMIMAT0001340MIRT042647CLASHFunctional MTI (Weak)23622248
hsa-miR-331-3pMIMAT0000760MIRT043387CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049695CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.