HCSGD entry for NLGN3

1. General information

Official gene symbolNLGN3
Entrez ID54413
Gene full nameneuroligin 3
Other gene symbolsHNL3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002087Regulation of respiratory gaseous exchange by neurological system processISSbiological_process
GO:0004872Receptor activityIBA ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005887Integral component of plasma membraneIBA ISScellular_component
GO:0006898Receptor-mediated endocytosisISSbiological_process
GO:0007155Cell adhesionIEAbiological_process
GO:0007158Neuron cell-cell adhesionISSbiological_process
GO:0007416Synapse assemblyIBA ISSbiological_process
GO:0007612LearningIMPbiological_process
GO:0008542Visual learningIEAbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0016020MembraneIEAcellular_component
GO:0030054Cell junctionIEAcellular_component
GO:0030139Endocytic vesicleISScellular_component
GO:0030534Adult behaviorIMPbiological_process
GO:0035176Social behaviorIMPbiological_process
GO:0042043Neurexin family protein bindingIBA ISSmolecular_function
GO:0045202SynapseIBA ISScellular_component
GO:0048675Axon extensionISSbiological_process
GO:0050804Regulation of synaptic transmissionISSbiological_process
GO:0050808Synapse organizationIMPbiological_process
GO:0050839Cell adhesion molecule bindingISSmolecular_function
GO:0051965Positive regulation of synapse assemblyISSbiological_process
GO:0051968Positive regulation of synaptic transmission, glutamatergicISSbiological_process
GO:0060024Rhythmic synaptic transmissionISSbiological_process
GO:0060076Excitatory synapseIDAcellular_component
GO:0060080Regulation of inhibitory postsynaptic membrane potentialISSbiological_process
GO:0061001Regulation of dendritic spine morphogenesisIEAbiological_process
GO:0071625Vocalization behaviorIMPbiological_process
GO:0097104Postsynaptic membrane assemblyISSbiological_process
GO:0097105Presynaptic membrane assemblyISSbiological_process
GO:1900271Regulation of long-term synaptic potentiationIEAbiological_process
GO:2000310Regulation of N-methyl-D-aspartate selective glutamate receptor activityIEAbiological_process
GO:2000331Regulation of terminal button organizationIEAbiological_process
GO:2000463Positive regulation of excitatory postsynaptic membrane potentialISSbiological_process
GO:2000969Positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activityISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.73188735230.78584953460.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0865461661
GSE13712_SHEARUp0.0953641311
GSE13712_STATICDown-0.0347659522
GSE19018Down-0.0679024916
GSE19899_A1Up0.0472494711
GSE19899_A2Down-0.0649437884
PubMed_21979375_A1Up0.0380682937
PubMed_21979375_A2Down-0.0596166450
GSE35957Up0.0528211054
GSE36640Down-0.0871788820
GSE54402Down-0.0826775688
GSE9593Up0.0990469805
GSE43922Up0.0385600233
GSE24585Down-0.0500148958
GSE37065Down-0.1270537208
GSE28863_A1Up0.1009430098
GSE28863_A2Up0.0259938843
GSE28863_A3Up0.3379628852
GSE28863_A4Up0.1378103820
GSE48662Up0.0454753235

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-122-5pMIMAT0000421MIRT023264MicroarrayFunctional MTI (Weak)17612493
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.