HCSGD entry for EXOSC4

1. General information

Official gene symbolEXOSC4
Entrez ID54512
Gene full nameexosome component 4
Other gene symbolsRRP41 RRP41A Rrp41p SKI6 Ski6p hRrp41p p12A
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:00001753'-5'-exoribonuclease activityNASmolecular_function
GO:0000178Exosome (RNase complex)IDAcellular_component
GO:0000288Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decayTASbiological_process
GO:0000460Maturation of 5.8S rRNAIMPbiological_process
GO:0000956Nuclear-transcribed mRNA catabolic processIMPbiological_process
GO:0004532Exoribonuclease activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusNAScellular_component
GO:0005737CytoplasmIDA NAScellular_component
GO:0005829CytosolTAScellular_component
GO:0006364RRNA processingNASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0017091AU-rich element bindingIDAmolecular_function
GO:0030307Positive regulation of cell growthIMPbiological_process
GO:0035327Transcriptionally active chromatinIMPcellular_component
GO:0043928Exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decayTASbiological_process
GO:0045006DNA deaminationIDAbiological_process
GO:0051607Defense response to virusIMPbiological_process
GO:0071028Nuclear mRNA surveillanceIMPbiological_process
GO:0071044Histone mRNA catabolic processIMPbiological_process
GO:0090305Nucleic acid phosphodiester bond hydrolysisNASbiological_process
GO:0090501RNA phosphodiester bond hydrolysisNASbiological_process
GO:0090503RNA phosphodiester bond hydrolysis, exonucleolyticNASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00528548690.76958793740.19005368851.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.8815805805
GSE13712_SHEARUp0.0337163111
GSE13712_STATICDown-0.0601658435
GSE19018Down-0.0299298735
GSE19899_A1Up1.1440953278
GSE19899_A2Up1.5044262191
PubMed_21979375_A1Up2.0830487777
PubMed_21979375_A2Up1.2984692274
GSE35957Down-0.2820716516
GSE36640Up0.3764209444
GSE54402Up0.7766667474
GSE9593Down-0.3774172498
GSE43922Up1.1463069837
GSE24585Down-0.2975882542
GSE37065Up0.1661841430
GSE28863_A1Down-0.3766929861
GSE28863_A2Down-0.3259993698
GSE28863_A3Down-0.1585521934
GSE28863_A4Up0.0097628248
GSE48662Up0.1265486895

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.