HCSGD entry for PPIA
1. General information
| Official gene symbol | PPIA |
|---|---|
| Entrez ID | 5478 |
| Gene full name | peptidylprolyl isomerase A (cyclophilin A) |
| Other gene symbols | CYPA CYPH |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000413 | Protein peptidyl-prolyl isomerization | IDA | biological_process |
| GO:0002576 | Platelet degranulation | TAS | biological_process |
| GO:0003755 | Peptidyl-prolyl cis-trans isomerase activity | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005829 | Cytosol | IDA TAS | cellular_component |
| GO:0006278 | RNA-dependent DNA replication | TAS | biological_process |
| GO:0006457 | Protein folding | IEA TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0016032 | Viral process | TAS | biological_process |
| GO:0019061 | Uncoating of virus | TAS | biological_process |
| GO:0019068 | Virion assembly | TAS | biological_process |
| GO:0019076 | Viral release from host cell | TAS | biological_process |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0030260 | Entry into host cell | TAS | biological_process |
| GO:0034389 | Lipid particle organization | IMP | biological_process |
| GO:0042277 | Peptide binding | IEA | molecular_function |
| GO:0045069 | Regulation of viral genome replication | IMP TAS | biological_process |
| GO:0045070 | Positive regulation of viral genome replication | IMP | biological_process |
| GO:0046790 | Virion binding | NAS | molecular_function |
| GO:0050714 | Positive regulation of protein secretion | IMP | biological_process |
| GO:0050900 | Leukocyte migration | TAS | biological_process |
| GO:0051082 | Unfolded protein binding | TAS | molecular_function |
| GO:0075713 | Establishment of integrated proviral latency | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9777602751 | 0.1794112534 | 0.9999902473 | 0.8203742059 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0296785421 |
| GSE13712_SHEAR | Up | 0.0268647860 |
| GSE13712_STATIC | Down | -0.0344063743 |
| GSE19018 | Down | -0.0185427249 |
| GSE19899_A1 | Down | -0.2247632480 |
| GSE19899_A2 | Down | -0.3079209316 |
| PubMed_21979375_A1 | Down | -0.2640433228 |
| PubMed_21979375_A2 | Down | -0.1173299587 |
| GSE35957 | Down | -0.1287380740 |
| GSE36640 | Down | -0.1437889050 |
| GSE54402 | Down | -0.0639902097 |
| GSE9593 | Down | -0.0019279018 |
| GSE43922 | Down | -0.5227151970 |
| GSE24585 | Up | 0.3401127217 |
| GSE37065 | Down | -0.1680023913 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.2265904741 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Cyclosporine | DB00091 | BTD00003 | BIOD00003 |
| (3r)-1-Acetyl-3-Methylpiperidine | DB01742 | EXPT00079 |
| Ethyl Oxo(Piperidin-1-Yl)Acetate | DB02419 | EXPT01313 |
| (3s,6s,9r,10r,11s,12s,13e,15e,18s,21s)-18-{(1e,3e,7s,8s)-9-[(2s,3r,4s,5s,6r,9s,11s)-9-Ethyl-4-Hydroxy-3,5,11-Trimethyl-8-Oxo-1-Oxa-7-Azaspiro[5.5]Undec-2-Yl]-8-Hydroxy-1,7-Dimethylnona-1,3-Dienyl}-10,12-Dihydroxy-3-(3-Hydroxybenzyl)-6-Isopropyl-11-Methyl- | DB03393 | EXPT02889 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT023905 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1307-3p | MIMAT0005951 | MIRT035823 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320b | MIMAT0005792 | MIRT036191 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1226-3p | MIMAT0005577 | MIRT036511 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-760 | MIMAT0004957 | MIRT036733 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-455-3p | MIMAT0004784 | MIRT037899 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-5p | MIMAT0004748 | MIRT038051 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-342-5p | MIMAT0004694 | MIRT038227 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-1-3p | MIMAT0004674 | MIRT038540 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-31-3p | MIMAT0004504 | MIRT038938 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040751 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043038 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT044321 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044403 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-218-5p | MIMAT0000275 | MIRT046998 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-197-3p | MIMAT0000227 | MIRT048054 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-26a-5p | MIMAT0000082 | MIRT050185 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT050690 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-3p | MIMAT0000071 | MIRT050789 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-3200-3p | MIMAT0015085 | MIRT052825 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
