HCSGD entry for PPL
1. General information
| Official gene symbol | PPL |
|---|---|
| Entrez ID | 5493 |
| Gene full name | periplakin |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005200 | Structural constituent of cytoskeleton | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0030057 | Desmosome | IEA | cellular_component |
| GO:0031424 | Keratinization | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0219220318 | 0.3591829528 | 0.3550546125 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1236758968 |
| GSE13712_SHEAR | Down | -0.9500975276 |
| GSE13712_STATIC | Down | -0.1190114766 |
| GSE19018 | Up | 0.1086758709 |
| GSE19899_A1 | Up | 0.1791558501 |
| GSE19899_A2 | Down | -0.5077722319 |
| PubMed_21979375_A1 | Down | -0.0124898856 |
| PubMed_21979375_A2 | Down | -0.1722004888 |
| GSE35957 | Down | -0.3736340661 |
| GSE36640 | Down | -0.0216551084 |
| GSE54402 | Down | -0.7473515401 |
| GSE9593 | Up | 2.6701793450 |
| GSE43922 | Up | 0.1722274828 |
| GSE24585 | Up | 0.3653293950 |
| GSE37065 | Down | -0.1139482573 |
| GSE28863_A1 | Up | 1.1005685156 |
| GSE28863_A2 | Up | 0.6579504950 |
| GSE28863_A3 | Up | 0.2091210960 |
| GSE28863_A4 | Up | 0.2259411556 |
| GSE48662 | Down | -0.0172016409 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT001519 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018065 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045015 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
