HCSGD entry for PPM1B
1. General information
| Official gene symbol | PPM1B |
|---|---|
| Entrez ID | 5495 |
| Gene full name | protein phosphatase, Mg2+/Mn2+ dependent, 1B |
| Other gene symbols | PP2C-beta-X PP2CB PP2CBETA PPC2BETAX |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000287 | Magnesium ion binding | IEA | molecular_function |
| GO:0004722 | Protein serine/threonine phosphatase activity | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005829 | Cytosol | ISS TAS | cellular_component |
| GO:0006470 | Protein dephosphorylation | IEA IMP | biological_process |
| GO:0006499 | N-terminal protein myristoylation | ISS | biological_process |
| GO:0016020 | Membrane | ISS | cellular_component |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0030145 | Manganese ion binding | IEA | molecular_function |
| GO:0032688 | Negative regulation of interferon-beta production | IMP | biological_process |
| GO:0035970 | Peptidyl-threonine dephosphorylation | IDA | biological_process |
| GO:0042347 | Negative regulation of NF-kappaB import into nucleus | IMP | biological_process |
| GO:0043124 | Negative regulation of I-kappaB kinase/NF-kappaB signaling | IMP | biological_process |
| GO:0050687 | Negative regulation of defense response to virus | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4905076745 | 0.1214984537 | 0.9999902473 | 0.6700106432 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2978355048 |
| GSE13712_SHEAR | Down | -0.0311229451 |
| GSE13712_STATIC | Down | -0.1102385395 |
| GSE19018 | Up | 0.8495382168 |
| GSE19899_A1 | Down | -0.6581328632 |
| GSE19899_A2 | Down | -0.5822676604 |
| PubMed_21979375_A1 | Down | -0.1802882017 |
| PubMed_21979375_A2 | Down | -0.9601010353 |
| GSE35957 | Up | 0.3224409348 |
| GSE36640 | Down | -0.2211621702 |
| GSE54402 | Down | -0.1004314610 |
| GSE9593 | Down | -0.0364824177 |
| GSE43922 | Down | -0.4203208867 |
| GSE24585 | Down | -0.2350149851 |
| GSE37065 | Down | -0.0010068223 |
| GSE28863_A1 | Up | 0.1134372965 |
| GSE28863_A2 | Up | 0.3526354202 |
| GSE28863_A3 | Down | -0.0831988262 |
| GSE28863_A4 | Down | -0.0038263908 |
| GSE48662 | Up | 0.0262305167 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-106b-5p | MIMAT0000680 | MIRT044250 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24674756 | PPM1B depletion induces premature senescence in human IMR-90 fibroblasts |
| 24674756 | PPM1B is a member of the protein phosphatase 2C family and plays a role in negatively regulating p53 and NF-kappaB thereby possibly attenuating the gene expression program of cellular senescence |
| 24674756 | PPM1B protein levels are progressively decreased in a replicative age-dependent manner |
| 24674756 | Importantly, PPM1B depletion induces a robust senescence phenotype as evidenced by significant growth arrest and senescence marker expression |
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