HCSGD entry for PPOX
1. General information
| Official gene symbol | PPOX |
|---|---|
| Entrez ID | 5498 |
| Gene full name | protoporphyrinogen oxidase |
| Other gene symbols | PPO V290M VP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004729 | Oxygen-dependent protoporphyrinogen oxidase activity | IDA TAS | molecular_function |
| GO:0005758 | Mitochondrial intermembrane space | TAS | cellular_component |
| GO:0006778 | Porphyrin-containing compound metabolic process | TAS | biological_process |
| GO:0006779 | Porphyrin-containing compound biosynthetic process | IDA | biological_process |
| GO:0006782 | Protoporphyrinogen IX biosynthetic process | IEA | biological_process |
| GO:0006783 | Heme biosynthetic process | IDA TAS | biological_process |
| GO:0016491 | Oxidoreductase activity | IEA | molecular_function |
| GO:0031304 | Intrinsic component of mitochondrial inner membrane | ISS | cellular_component |
| GO:0031305 | Integral component of mitochondrial inner membrane | IEA | cellular_component |
| GO:0031966 | Mitochondrial membrane | IMP | cellular_component |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0050660 | Flavin adenine dinucleotide binding | TAS | molecular_function |
| GO:0055114 | Oxidation-reduction process | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8539881957 | 0.6365448881 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0304160805 |
| GSE13712_SHEAR | Down | -0.2959557482 |
| GSE13712_STATIC | Down | -0.1419534927 |
| GSE19018 | Up | 0.1213618084 |
| GSE19899_A1 | Up | 0.0541673813 |
| GSE19899_A2 | Up | 0.1085094565 |
| PubMed_21979375_A1 | Up | 0.0736286852 |
| PubMed_21979375_A2 | Up | 0.1784976714 |
| GSE35957 | Up | 0.0796413589 |
| GSE36640 | Up | 0.1405657167 |
| GSE54402 | Down | -0.0290248804 |
| GSE9593 | Down | -0.0086838956 |
| GSE43922 | Up | 0.0237090944 |
| GSE24585 | Up | 0.1995573372 |
| GSE37065 | Down | -0.0578492877 |
| GSE28863_A1 | Down | -0.1516827433 |
| GSE28863_A2 | Down | -0.0350727338 |
| GSE28863_A3 | Down | -0.2061580929 |
| GSE28863_A4 | Down | -0.1437538081 |
| GSE48662 | Down | -0.0067357004 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028501 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
