HCSGD entry for UACA
1. General information
| Official gene symbol | UACA |
|---|---|
| Entrez ID | 55075 |
| Gene full name | uveal autoantigen with coiled-coil domains and ankyrin repeats |
| Other gene symbols | NUCLING |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003674 | Molecular_function | ND | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | NAS | cellular_component |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005635 | Nuclear envelope | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0008150 | Biological_process | ND | biological_process |
| GO:0008630 | Intrinsic apoptotic signaling pathway in response to DNA damage | IEA | biological_process |
| GO:0008631 | Intrinsic apoptotic signaling pathway in response to oxidative stress | IEA | biological_process |
| GO:0009411 | Response to UV | IEA | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0042307 | Positive regulation of protein import into nucleus | IEA | biological_process |
| GO:0042347 | Negative regulation of NF-kappaB import into nucleus | IEA | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | IEA | biological_process |
| GO:0043280 | Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | IEA | biological_process |
| GO:0043293 | Apoptosome | IEA | cellular_component |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0050728 | Negative regulation of inflammatory response | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0130043311 | 0.3582053265 | 0.2841881426 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3447616952 |
| GSE13712_SHEAR | Up | 0.2370759442 |
| GSE13712_STATIC | Down | -0.1531625438 |
| GSE19018 | Up | 0.1095771005 |
| GSE19899_A1 | Up | 1.1369143625 |
| GSE19899_A2 | Down | -0.3192390878 |
| PubMed_21979375_A1 | Down | -1.5635105375 |
| PubMed_21979375_A2 | Up | 0.0923404687 |
| GSE35957 | Up | 0.8517537258 |
| GSE36640 | Up | 1.5981691525 |
| GSE54402 | Down | -0.0566241844 |
| GSE9593 | Up | 0.5518242377 |
| GSE43922 | Down | -0.0028516366 |
| GSE24585 | Up | 0.1083554343 |
| GSE37065 | Down | -0.2412927632 |
| GSE28863_A1 | Up | 0.5338316197 |
| GSE28863_A2 | Up | 0.8614607840 |
| GSE28863_A3 | Down | -0.3343588404 |
| GSE28863_A4 | Up | 0.2121891003 |
| GSE48662 | Up | 0.0269703538 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024757 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026209 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-940 | MIMAT0004983 | MIRT036623 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-15b-5p | MIMAT0000417 | MIRT046407 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
