HCSGD entry for ZNF331
1. General information
| Official gene symbol | ZNF331 |
|---|---|
| Entrez ID | 55422 |
| Gene full name | zinc finger protein 331 |
| Other gene symbols | RITA ZNF361 ZNF463 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0008270 | Zinc ion binding | NAS | molecular_function |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9479455606 | 0.0287956423 | 0.9999902473 | 0.3223380527 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -3.0470296805 |
| GSE13712_SHEAR | Down | -0.2754865626 |
| GSE13712_STATIC | Down | -0.4829951548 |
| GSE19018 | Down | -0.0390692792 |
| GSE19899_A1 | Up | 0.0148381400 |
| GSE19899_A2 | Down | -0.5867319082 |
| PubMed_21979375_A1 | Down | -0.4243274380 |
| PubMed_21979375_A2 | Down | -0.5707384073 |
| GSE35957 | Up | 0.1126637842 |
| GSE36640 | Down | -0.3619568569 |
| GSE54402 | Down | -0.4980064870 |
| GSE9593 | Up | 0.3482652732 |
| GSE43922 | Down | -0.0133740006 |
| GSE24585 | Down | -0.3868585309 |
| GSE37065 | Up | 0.1135317218 |
| GSE28863_A1 | Up | 0.1681397345 |
| GSE28863_A2 | Up | 0.1196937053 |
| GSE28863_A3 | Down | -0.2740826606 |
| GSE28863_A4 | Up | 0.0078305471 |
| GSE48662 | Up | 0.0254464631 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-20a-5p | MIMAT0000075 | MIRT050511 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22370639 | Zinc-finger protein 331 (ZNF331), a Kruppel-associated box zinc-finger protein gene, was identified as a putative tumor suppressor in our previous study |
| 22370639 | However, the role of ZNF331 in tumorigenesis remains elusive |
| 22370639 | ZNF331 was silenced or downregulated in 71% (12/17) gastric cancer cell lines |
| 22370639 | In contrast, ZNF331 was readily expressed in various normal adult tissues |
| 22370639 | The downregulation of ZNF331 was closely linked to the promoter hypermethylation as evidenced by methylation-specific PCR, bisulfite genomic sequencing and reexpression by demethylation agent treatment |
| 22370639 | DNA sequencing showed no genetic mutation/deletion of ZNF331 in gastric cancer cell lines |
| 22370639 | Ectopic expression of ZNF331 in the silenced cancer cell lines MKN28 and HCT116 significantly reduced colony formation and cell viability, induced cell cycle arrests and repressed cell migration and invasive ability |
| 22370639 | Two-dimensional gel electrophoresis and mass spectrometry-based comparative proteomic approach were applied to analyze the molecular basis of the biological functions of ZNF331 |
| 22370639 | In all, 10 downstream targets of ZNF331 were identified to be associated with regulation of cell growth and metastasis |
| 22370639 | A novel target of ZNF331 (DSTN) was functionally validated |
| 22370639 | In conclusion, our results suggest that ZNF331 possesses important functions for the suppression of gastric carcinogenesis as a novel functional tumor-suppressor gene |
| 21764762 | Accordingly, treatment of certain wild-type p53-expressing tumor cell lines with the p53-reactivating small molecular compound RITA resulted in upregulation of ULBP2 mRNA and cell surface protein expression |
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