HCSGD entry for PRIM1
1. General information
| Official gene symbol | PRIM1 |
|---|---|
| Entrez ID | 5557 |
| Gene full name | primase, DNA, polypeptide 1 (49kDa) |
| Other gene symbols | p49 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000722 | Telomere maintenance via recombination | TAS | biological_process |
| GO:0000723 | Telomere maintenance | TAS | biological_process |
| GO:0003896 | DNA primase activity | IEA | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006269 | DNA replication, synthesis of RNA primer | TAS | biological_process |
| GO:0006270 | DNA replication initiation | TAS | biological_process |
| GO:0006271 | DNA strand elongation involved in DNA replication | TAS | biological_process |
| GO:0032201 | Telomere maintenance via semi-conservative replication | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:1990077 | Primosome complex | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9670440675 | 0.0000776110 | 0.9999902473 | 0.0148833333 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.6379394120 |
| GSE13712_SHEAR | Down | -0.5963461210 |
| GSE13712_STATIC | Down | -0.4847075400 |
| GSE19018 | Down | -0.0582267850 |
| GSE19899_A1 | Down | -0.6407222027 |
| GSE19899_A2 | Down | -5.1765213166 |
| PubMed_21979375_A1 | Down | -1.4090323099 |
| PubMed_21979375_A2 | Down | -5.3797770242 |
| GSE35957 | Down | -2.8192481802 |
| GSE36640 | Down | -4.2018745487 |
| GSE54402 | Down | -0.6555672263 |
| GSE9593 | Down | -1.9383063034 |
| GSE43922 | Down | -2.1026338772 |
| GSE24585 | Up | 0.1397456395 |
| GSE37065 | Down | -0.3442817819 |
| GSE28863_A1 | Down | -0.0255367258 |
| GSE28863_A2 | Up | 0.5969446320 |
| GSE28863_A3 | Down | -0.0767631567 |
| GSE28863_A4 | Up | 0.3857265247 |
| GSE48662 | Down | -0.4844080072 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT000895 | Microarray | Functional MTI (Weak) | 18362358 |
| hsa-miR-15a-5p | MIMAT0000068 | MIRT000896 | Microarray | Functional MTI (Weak) | 18362358 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT001604 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016373 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024825 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025399 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026411 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028506 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030386 | Microarray | Functional MTI (Weak) | 19748357 |
| hsa-miR-197-3p | MIMAT0000227 | MIRT048061 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-15a-5p | MIMAT0000068 | NA | hsa-miR-15a | 18362358 | |||
| hsa-miR-16-5p | MIMAT0000069 | NA | hsa-miR-16 | 18362358 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25183317 | The endogenous p49/SRAP protein was localized mainly in the nucleus but also widely distributed in the cytoplasm, and was in close proximity to the actin |
| 25183317 | CONCLUSIONS: Since p49/STRAP is a co-factor of SRF, our data suggest that p49/STRAP likely regulates cell size and morphology through SRF target genes |
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