HCSGD entry for CAND1
1. General information
| Official gene symbol | CAND1 |
|---|---|
| Entrez ID | 55832 |
| Gene full name | cullin-associated and neddylation-dissociated 1 |
| Other gene symbols | TIP120 TIP120A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000151 | Ubiquitin ligase complex | IDA | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0010265 | SCF complex assembly | IDA | biological_process |
| GO:0016567 | Protein ubiquitination | IDA | biological_process |
| GO:0017025 | TBP-class protein binding | IEA | molecular_function |
| GO:0030154 | Cell differentiation | IDA | biological_process |
| GO:0031461 | Cullin-RING ubiquitin ligase complex | IDA | cellular_component |
| GO:0043086 | Negative regulation of catalytic activity | IDA | biological_process |
| GO:0045899 | Positive regulation of RNA polymerase II transcriptional preinitiation complex assembly | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9710050454 | 0.0191905893 | 0.9999902473 | 0.2708311064 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4043714541 |
| GSE13712_SHEAR | Down | -0.2059064102 |
| GSE13712_STATIC | Down | -0.1579591994 |
| GSE19018 | Down | -0.1511273434 |
| GSE19899_A1 | Down | -0.2198426672 |
| GSE19899_A2 | Down | -0.5748983385 |
| PubMed_21979375_A1 | Down | -0.5110147356 |
| PubMed_21979375_A2 | Down | -0.4740202484 |
| GSE35957 | Down | -0.2180990181 |
| GSE36640 | Down | -0.2669815974 |
| GSE54402 | Down | -0.1708847005 |
| GSE9593 | Down | -0.3025502132 |
| GSE43922 | Down | -0.0341400444 |
| GSE24585 | Down | -0.1239092616 |
| GSE37065 | Down | -0.0853055985 |
| GSE28863_A1 | Up | 0.5976572563 |
| GSE28863_A2 | Up | 0.2586989046 |
| GSE28863_A3 | Down | -0.8337195464 |
| GSE28863_A4 | Down | -0.1331296465 |
| GSE48662 | Up | 0.3458125418 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT001378 | Luciferase reporter assay//Microarray | Functional MTI | 15685193 |
| hsa-miR-1 | MIMAT0000416 | MIRT001378 | pSILAC//Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1 | MIMAT0000416 | MIRT001378 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-1301-3p | MIMAT0005797 | MIRT036016 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1296-5p | MIMAT0005794 | MIRT036143 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-425-5p | MIMAT0003393 | MIRT039318 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-195-5p | MIMAT0000461 | MIRT044866 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045132 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | NA | hsa-miR-1 | 15685193 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
