HCSGD entry for PSENEN

1. General information

Official gene symbolPSENEN
Entrez ID55851
Gene full namepresenilin enhancer 2 homolog (C. elegans)
Other gene symbolsMSTP064 PEN-2 PEN2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005515Protein bindingIPImolecular_function
GO:0005783Endoplasmic reticulumIDAcellular_component
GO:0005789Endoplasmic reticulum membraneIEAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0006509Membrane protein ectodomain proteolysisIDAbiological_process
GO:0007219Notch signaling pathwayTASbiological_process
GO:0007220Notch receptor processingTASbiological_process
GO:0016485Protein processingIDAbiological_process
GO:0031293Membrane protein intracellular domain proteolysisTASbiological_process
GO:0032580Golgi cisterna membraneIEAcellular_component
GO:0042987Amyloid precursor protein catabolic processTASbiological_process
GO:0043065Positive regulation of apoptotic processTASbiological_process
GO:0043085Positive regulation of catalytic activityIDAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00362470270.99051194100.16308683761.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.8134940936
GSE13712_SHEARDown-0.0309759083
GSE13712_STATICDown-0.1939787337
GSE19018Up0.1236873775
GSE19899_A1Up1.1919931902
GSE19899_A2Up1.0090333054
PubMed_21979375_A1Up1.1936648438
PubMed_21979375_A2Up0.6093007367
GSE35957Up0.1457822667
GSE36640Up0.1615826465
GSE54402Up0.6872939022
GSE9593Up0.5794325482
GSE43922Up0.7249897269
GSE24585Up0.1103451447
GSE37065Down-0.1571984797
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.3658571946

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

E2012DB05171 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.