HCSGD entry for MAP2K2

1. General information

Official gene symbolMAP2K2
Entrez ID5605
Gene full namemitogen-activated protein kinase kinase 2
Other gene symbolsMAPKK2 MEK2 MKK2 PRKMK2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000165MAPK cascadeTASbiological_process
GO:0000186Activation of MAPKK activityTASbiological_process
GO:0000187Activation of MAPK activityTASbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0004674Protein serine/threonine kinase activityIEA TASmolecular_function
GO:0004708MAP kinase kinase activityIDA IEAmolecular_function
GO:0004712Protein serine/threonine/tyrosine kinase activityTASmolecular_function
GO:0004713Protein tyrosine kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005576Extracellular regionNAScellular_component
GO:0005634NucleusTAScellular_component
GO:0005739MitochondrionTAScellular_component
GO:0005769Early endosomeTAScellular_component
GO:0005770Late endosomeTAScellular_component
GO:0005778Peroxisomal membraneIDAcellular_component
GO:0005783Endoplasmic reticulumIDAcellular_component
GO:0005794Golgi apparatusIDA TAScellular_component
GO:0005829CytosolIEA TAScellular_component
GO:0005874MicrotubuleIDAcellular_component
GO:0005911Cell-cell junctionIDAcellular_component
GO:0005925Focal adhesionTAScellular_component
GO:0005938Cell cortexIEAcellular_component
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0007265Ras protein signal transductionTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0008286Insulin receptor signaling pathwayTASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0009898Cytoplasmic side of plasma membraneIDAcellular_component
GO:0016772Transferase activity, transferring phosphorus-containing groupsIEAmolecular_function
GO:0030165PDZ domain bindingIDAmolecular_function
GO:0032872Regulation of stress-activated MAPK cascadeTASbiological_process
GO:0032947Protein complex scaffoldIEAmolecular_function
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0036289Peptidyl-serine autophosphorylationIDAbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0043539Protein serine/threonine kinase activator activityIDAmolecular_function
GO:0045087Innate immune responseTASbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0051403Stress-activated MAPK cascadeTASbiological_process
GO:0070371ERK1 and ERK2 cascadeTASbiological_process
GO:0071902Positive regulation of protein serine/threonine kinase activityIDAbiological_process
GO:0090170Regulation of Golgi inheritanceTASbiological_process
GO:0097110Scaffold protein bindingIPImolecular_function
GO:2000147Positive regulation of cell motilityIEAbiological_process
GO:2000641Regulation of early endosome to late endosome transportTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.13180689180.80082302340.73657944801.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1827301126
GSE13712_SHEARDown-0.1618551259
GSE13712_STATICDown-0.1976861586
GSE19018Up0.1531384775
GSE19899_A1Down-0.0840896923
GSE19899_A2Up0.8524596449
PubMed_21979375_A1Up0.5397373013
PubMed_21979375_A2Up0.5292719273
GSE35957Down-0.4098153648
GSE36640Up0.1211099566
GSE54402Up0.2824669507
GSE9593Up0.4209190697
GSE43922Up0.0535934885
GSE24585Up0.1655399101
GSE37065Down-0.2988576023
GSE28863_A1Up0.0212581944
GSE28863_A2Down-0.1971645996
GSE28863_A3Up0.0720124542
GSE28863_A4Up0.0925159617
GSE48662Up0.1199478281

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

BosutinibDB06616 -
TrametinibDB08911 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-7-5pMIMAT0000252MIRT025900MicroarrayFunctional MTI (Weak)19073608
hsa-let-7b-5pMIMAT0000063MIRT032459ProteomicsFunctional MTI (Weak)18668040
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.