HCSGD entry for PROC

1. General information

Official gene symbolPROC
Entrez ID5624
Gene full nameprotein C (inactivator of coagulation factors Va and VIIIa)
Other gene symbolsAPC PC PROC1 THPH3 THPH4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004252Serine-type endopeptidase activityIEA TASmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEA NAS TAScellular_component
GO:0005788Endoplasmic reticulum lumenTAScellular_component
GO:0005796Golgi lumenTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006508ProteolysisIEA NAS TASbiological_process
GO:0007596Blood coagulationIEA TASbiological_process
GO:0008233Peptidase activityIEAmolecular_function
GO:0017187Peptidyl-glutamic acid carboxylationTASbiological_process
GO:0030195Negative regulation of blood coagulationIEA TASbiological_process
GO:0043066Negative regulation of apoptotic processIMPbiological_process
GO:0043687Post-translational protein modificationTASbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0050900Leukocyte migrationTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.71892733560.77037619010.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0469769651
GSE13712_SHEARDown-0.0520791021
GSE13712_STATICUp0.1408976527
GSE19018Up0.1348024183
GSE19899_A1Down-0.1432434911
GSE19899_A2Up0.0471457443
PubMed_21979375_A1Up0.0155101697
PubMed_21979375_A2Down-0.1826570837
GSE35957Down-0.1376975554
GSE36640Up0.1698787893
GSE54402Up0.0004431051
GSE9593Down-0.0812794239
GSE43922Up0.0138646840
GSE24585Up0.1161957746
GSE37065Down-0.0095318676
GSE28863_A1Down-0.0625818423
GSE28863_A2Up0.0798070004
GSE28863_A3Up0.3549366849
GSE28863_A4Up0.1445476604
GSE48662Down-0.0603895232

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

MenadioneDB00170 NUTR00062

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-135a-5pMIMAT0000428NAhsa-miR-135a18632633
hsa-miR-135b-5pMIMAT0000758NAhsa-miR-135b{Western blot}{overexpression}18632633
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23268535These four genes encode two surfactant proteins, surfactant protein C (encoded by SFTPC) and surfactant protein A2 (SFTPA2), and two components of the telomerase complex, telomerase reverse transcriptase (TERT) and the RNA component of telomerase (TERC)
21866419Because of their multiple properties that are characteristic of a private response of the parental cell, MPs could act as cytoprotective and anti-inflammatory agents through the delivery of activated protein C or annexin 1 and could contribute to the limitation of vascular hyporeactivity
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