HCSGD entry for RNF20

1. General information

Official gene symbolRNF20
Entrez ID56254
Gene full namering finger protein 20, E3 ubiquitin protein ligase
Other gene symbolsBRE1 BRE1A hBRE1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000151Ubiquitin ligase complexIDAcellular_component
GO:0000209Protein polyubiquitinationIDAbiological_process
GO:0002039P53 bindingIDAmolecular_function
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003713Transcription coactivator activityIDAmolecular_function
GO:0004842Ubiquitin-protein ligase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0006355Regulation of transcription, DNA-templatedIMPbiological_process
GO:0006511Ubiquitin-dependent protein catabolic processIMPbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0010390Histone monoubiquitinationIDAbiological_process
GO:0016574Histone ubiquitinationIEAbiological_process
GO:0030336Negative regulation of cell migrationIDAbiological_process
GO:0031062Positive regulation of histone methylationIEAbiological_process
GO:0031625Ubiquitin protein ligase bindingIPImolecular_function
GO:0033503HULC complexIDAcellular_component
GO:0033523Histone H2B ubiquitinationIDAbiological_process
GO:0042393Histone bindingIDAmolecular_function
GO:0045893Positive regulation of transcription, DNA-templatedIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.31030146270.83069536870.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0618561144
GSE13712_SHEARDown-0.1024923405
GSE13712_STATICDown-0.0884300348
GSE19018Up0.1875698509
GSE19899_A1Down-0.0479133470
GSE19899_A2Down-0.3599712861
PubMed_21979375_A1Down-0.4696084221
PubMed_21979375_A2Up0.1783243964
GSE35957Up0.2025819658
GSE36640Up0.1272718093
GSE54402Up0.0141328448
GSE9593Up0.2452189938
GSE43922Up0.0449994716
GSE24585Up0.5316828670
GSE37065Down-0.0561707841
GSE28863_A1Up0.1070226698
GSE28863_A2Up0.1250275056
GSE28863_A3Down-0.0731647091
GSE28863_A4Up0.1192589621
GSE48662Down-0.0137131873

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-221-3pMIMAT0000278MIRT024169SequencingFunctional MTI (Weak)20371350
hsa-miR-1296-5pMIMAT0005794MIRT036112CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24025678Moreover, deficiencies in the H2B ubiquitylase complex Rad6/Bre1 as well as the deubiquitylase Ubp10 reduced the lifespan by altering both H3K4 and H3K79 methylation and Sir2 recruitment
21481687Taken together, our results suggest that uH2B is a novel direct or indirect chromatin target of resveratrol and RNF20 plays an important role in inhibiting cellular senescence programs that are intact in glioma cells
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