HCSGD entry for POLE4
1. General information
| Official gene symbol | POLE4 |
|---|---|
| Entrez ID | 56655 |
| Gene full name | polymerase (DNA-directed), epsilon 4, accessory subunit |
| Other gene symbols | YHHQ1 p12 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003887 | DNA-directed DNA polymerase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex | IDA | cellular_component |
| GO:0006261 | DNA-dependent DNA replication | TAS | biological_process |
| GO:0008622 | Epsilon DNA polymerase complex | IDA | cellular_component |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0043966 | Histone H3 acetylation | IDA | biological_process |
| GO:0046982 | Protein heterodimerization activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4788150108 | 0.2186951446 | 0.9999902473 | 0.8995585091 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1260257114 |
| GSE13712_SHEAR | Up | 0.4097202236 |
| GSE13712_STATIC | Up | 0.0955576182 |
| GSE19018 | Down | -0.0109039834 |
| GSE19899_A1 | Up | 0.0658433491 |
| GSE19899_A2 | Up | 0.1718199398 |
| PubMed_21979375_A1 | Up | 0.6999090911 |
| PubMed_21979375_A2 | Up | 0.0975627478 |
| GSE35957 | Down | -0.1616933751 |
| GSE36640 | Down | -0.2393497873 |
| GSE54402 | Up | 0.0923383054 |
| GSE9593 | Down | -0.1657928893 |
| GSE43922 | Down | -0.0008407665 |
| GSE24585 | Down | -0.2960648069 |
| GSE37065 | Down | -0.1785934634 |
| GSE28863_A1 | Down | -0.4973752881 |
| GSE28863_A2 | Up | 0.1828597145 |
| GSE28863_A3 | Down | -0.1537249267 |
| GSE28863_A4 | Down | -0.1024368603 |
| GSE48662 | Down | -0.4723099077 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT001520 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025793 | Microarray | Functional MTI (Weak) | 19073608 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
