HCSGD entry for FAM20C
1. General information
| Official gene symbol | FAM20C |
|---|---|
| Entrez ID | 56975 |
| Gene full name | family with sequence similarity 20, member C |
| Other gene symbols | DMP-4 DMP4 GEF-CK RNS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001501 | Skeletal system development | IEA | biological_process |
| GO:0004674 | Protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0030501 | Positive regulation of bone mineralization | IEA | biological_process |
| GO:0036179 | Osteoclast maturation | IEA | biological_process |
| GO:0040036 | Regulation of fibroblast growth factor receptor signaling pathway | IEA | biological_process |
| GO:0045669 | Positive regulation of osteoblast differentiation | IEA | biological_process |
| GO:0051174 | Regulation of phosphorus metabolic process | IEA | biological_process |
| GO:0070166 | Enamel mineralization | IEA | biological_process |
| GO:0071895 | Odontoblast differentiation | IEA | biological_process |
| GO:0097187 | Dentinogenesis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7674913643 | 0.2151378899 | 0.9999902473 | 0.8950548428 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0587206242 |
| GSE13712_SHEAR | Down | -0.6200338713 |
| GSE13712_STATIC | Down | -0.5901724096 |
| GSE19018 | Up | 0.1270569710 |
| GSE19899_A1 | Down | -0.0002615269 |
| GSE19899_A2 | Up | 0.6994240348 |
| PubMed_21979375_A1 | Up | 0.7197722771 |
| PubMed_21979375_A2 | Up | 0.3355736183 |
| GSE35957 | Down | -0.3618416042 |
| GSE36640 | Down | -0.1851540403 |
| GSE54402 | Down | -0.0310664284 |
| GSE9593 | Down | -0.2387098129 |
| GSE43922 | Up | 0.1222600414 |
| GSE24585 | Down | -0.2582527680 |
| GSE37065 | Down | -0.1670776652 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.0820536893 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049711 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 7 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27247702 | Besides changes in gene expression and metabolic control, the aging rate has been associated with the production of high levels of Reactive Oxygen Species (ROS) and/or Reactive Nitrosative Species (RNS) |
| 24057048 | Both Co-EPM and Co-ASS significantly reduced reactive oxygen/nitrogen species (ROS/RNS), and in turn nitrites, suggesting that the hexacarbonyldicobalt moiety may deliver CO within the cell, acting as a CO-releasing molecule (CO-RM) |
| 23192437 | Increased levels of reactive oxygen/nitrogen species (ROS/RNS) are associated with tissue injury and inflammation, impact a number of cellular processes, including cell adhesion, migration, and proliferation, and have been linked to cellular senescence in MSCs, potentially compromising their activities |
| 23192437 | Naturally occurring polyphenolic compounds (polyphenols), epigallocatechin-3-gallate (EGCG), and curcumin, block ROS/RNS and are potent inflammation-modulating agents |
| 22396858 | It has been shown that superoxide and nitric oxide together with their diamagnetic reaction products hydrogen peroxide and peroxynitrite (all are now named reactive oxygen and nitrogen species, ROS and RNS) function as signaling species in many physiological enzymatic/gene processes |
| 22396858 | Furthermore, the disturbance of ROS and RNS physiological signaling can be an origin of various pathologies and aging |
| 18924487 | However, reactive oxygen (ROS) and nitrogen species (RNS) are "two-faced" products |
| 16978905 | Reactive oxygen species (ROS) and reactive nitrogen species (RNS, e |
| 16978905 | In contrast, beneficial effects of ROS/RNS (e |
| 16978905 | This review will describe the: (i) chemistry and biochemistry of ROS/RNS and sources of free radical generation; (ii) damage to DNA, to proteins, and to lipids by free radicals; (iii) role of antioxidants (e |
| 16430879 | Oxygen-free radicals, more generally known as reactive oxygen species (ROS) along with reactive nitrogen species (RNS) are well recognised for playing a dual role as both deleterious and beneficial species |
| 16430879 | The cumulative production of ROS/RNS through either endogenous or exogenous insults is termed oxidative stress and is common for many types of cancer cell that are linked with altered redox regulation of cellular signalling pathways |
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