HCSGD entry for PSMB10

1. General information

Official gene symbolPSMB10
Entrez ID5699
Gene full nameproteasome (prosome, macropain) subunit, beta type, 10
Other gene symbolsLMP10 MECL1 beta2i
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000209Protein polyubiquitinationTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000502Proteasome complexTAScellular_component
GO:0000902Cell morphogenesisIEAbiological_process
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0004298Threonine-type endopeptidase activityIEAmolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0005839Proteasome core complexIEA ISScellular_component
GO:0006521Regulation of cellular amino acid metabolic processTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006959Humoral immune responseTASbiological_process
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestTASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016032Viral processTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTASbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042098T cell proliferationIEAbiological_process
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0051436Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051437Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051603Proteolysis involved in cellular protein catabolic processIEAbiological_process
GO:1990111Spermatoproteasome complexISScellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.37202648080.16048230690.99999024730.7737216508

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1265377133
GSE13712_SHEARDown-0.2566533007
GSE13712_STATICUp0.2556467924
GSE19018Up0.0523045225
GSE19899_A1Down-0.5885868178
GSE19899_A2Down-0.2520471452
PubMed_21979375_A1Up0.1908529485
PubMed_21979375_A2Down-0.4914082963
GSE35957Down-0.9030415205
GSE36640Up0.6663010141
GSE54402Down-0.0605243937
GSE9593Down-0.0715167196
GSE43922Up0.0543691166
GSE24585Down-0.2052127978
GSE37065Up0.3195993093
GSE28863_A1Up0.0114344977
GSE28863_A2Down-0.1783945240
GSE28863_A3Up0.0807015238
GSE28863_A4Up0.1698957054
GSE48662Up0.1370529035

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

CarfilzomibDB08889 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.