HCSGD entry for PSMC4

1. General information

Official gene symbolPSMC4
Entrez ID5704
Gene full nameproteasome (prosome, macropain) 26S subunit, ATPase, 4
Other gene symbolsMIP224 RPT3 S6 TBP-7 TBP7
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000209Protein polyubiquitinationTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000502Proteasome complexTAScellular_component
GO:0001824Blastocyst developmentIEAbiological_process
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006200ATP catabolic processTASbiological_process
GO:0006508ProteolysisTASbiological_process
GO:0006521Regulation of cellular amino acid metabolic processTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestTASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016032Viral processTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0016234Inclusion bodyIEAcellular_component
GO:0016887ATPase activityTASmolecular_function
GO:0022624Proteasome accessory complexISScellular_component
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTASbiological_process
GO:0031597Cytosolic proteasome complexIEAcellular_component
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0051436Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051437Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02189407700.94882917060.35505461251.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.6487253002
GSE13712_SHEARUp0.2129427645
GSE13712_STATICUp0.2668838991
GSE19018Down-0.1577552891
GSE19899_A1Up0.4621167411
GSE19899_A2Up0.7243719576
PubMed_21979375_A1Up1.2937064539
PubMed_21979375_A2Up0.6482138963
GSE35957Down-0.3817314144
GSE36640Up0.1601912578
GSE54402Up0.9399011963
GSE9593Down-0.1092424475
GSE43922Up0.3699656424
GSE24585Down-0.1715001599
GSE37065Up0.0987744899
GSE28863_A1Down-0.0636639789
GSE28863_A2Up0.0332938059
GSE28863_A3Down-0.3328456569
GSE28863_A4Up0.0177045073
GSE48662Down-0.0015096169

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029325MicroarrayFunctional MTI (Weak)19088304
hsa-miR-877-3pMIMAT0004950MIRT036915CLASHFunctional MTI (Weak)23622248
hsa-miR-331-3pMIMAT0000760MIRT043323CLASHFunctional MTI (Weak)23622248
hsa-miR-222-3pMIMAT0000279MIRT046684CLASHFunctional MTI (Weak)23622248
hsa-miR-15a-5pMIMAT0000068MIRT051335CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.